Results 171 to 180 of about 168,658 (234)

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

Essays in Biochemistry, 2002
The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases.
Janelle, Nunan, David H, Small
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Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Biochemical and Biophysical Research Communications, 1987
The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a
T, Yamada, H, Sasaki, H, Furuya, T, Miyata, I, Goto, Y, Sakaki   +5 more
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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Science, 1994
Normal processing of the amyloid β protein precursor (βAPP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid β protein (Aβ) that forms insoluble fibrillar deposits in Alzheimer's disease.
N, Suzuki, T T, Cheung, X D, Cai, A, Odaka, L, Otvos, C, Eckman, T E, Golde, S G, Younkin   +7 more
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Low cerebrospinal-fluid concentrations of soluble amyloid $beta;-protein precursor in hereditary Alzheimer's disease

The Lancet, 1992
In Alzheimer's disease, deposits of amyloid beta-protein are apparently derived from intracellular processing of a large precursor protein. We have measured concentrations of this precursor in cerebrospinal fluid (CSF) from six members of a family affected by presenile Alzheimer's disease associated with a point mutation of the precursor gene. One gene
M, Farlow, B, Ghetti, M D, Benson, J S, Farrow, W E, van Nostrand, S L, Wagner   +5 more
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Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling, R N, Martins, M, Racchi, S, Craft, E, Helmerhorst   +4 more
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Stimulated platelets release amyloid β-protein precursor

Biochemical and Biophysical Research Communications, 1990
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of ...
G M, Cole, D, Galasko, I P, Shapiro, T, Saitoh   +3 more
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Isoform Specific Amyloid-β Protein Precursor Metabolism

Journal of Alzheimer's Disease, 2007
Alzheimer's amyloid-β protein precursor (AβPP) can occur in different isoforms, among them AβPP751, which is the most abundant isoform in non-neuronal tissues, and AβPP695, often referred to as the neuronal isoform. However, few isoform-specific roles have been addressed.
Ana Gabriela, Henriques, Sandra Isabel, Vieira, Sandra, Rebelo, Sara C T S, Domingues, Edgar F, da Cruz e Silva, Odete A B, da Cruz e Silva   +5 more
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Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes

Annals of Neurology, 2003
AbstractThe amyloid‐β protein precursor, a type 1 transmembrane protein, gives rise to the amyloid β‐protein, a neurotoxic peptide postulated to be involved in the pathogenesis of Alzheimer's disease. Here, we show that soluble amyloid β protein accelerates amyloid precursor protein complex formation, a process that contributes to neuronal cell death ...
Daniel C, Lu, Gideon M, Shaked, Eliezer, Masliah, Dale E, Bredesen, Edward H, Koo   +4 more
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Localization of Alzheimer Amyloid Beta Protein Precursor and Its Relation to Senile Plaque Amyloid

Gerontology, 1994
The authors examined the ultrastructural localization of amyloid beta protein precursor (APP) in normal human brains immunohistochemically using 3 kinds of APP antisera. The patterns of immunoreaction differed between the antisera used. Antiserum 770, against APP1-770, predominantly labeled the cytoplasm of neurons, whereas antiserum Z31, against the ...
H, Yamaguchi, T, Yamazaki, T, Kawarabayashi, X, Sun, Y, Sakai, S, Hirai   +5 more
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Expression of amyloid beta-protein precursor mRNAs in familial Alzheimerʼs disease

NeuroReport, 1991
The amyloid beta-protein precursor (APP) gene and its products are implicated in the pathogenesis of Alzheimer's disease. The differential expression of APP transcripts may contribute to this process. In the present study, the distribution of mRNAs encoding APP variants has been determined in the brain of three cases of familial Alzheimer's disease ...
P J, Harrison, A J, Barton, R C, Pearson
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