Results 191 to 200 of about 94,035 (378)

P1-153: DDT EXPOSURE INCREASES LEVELS OF THE AMYLOID PRECURSOR PROTEIN, AMYLOID BETA, AND PROINFLAMMATORY FACTORS: MECHANISTIC LINKS TO ALZHEIMER'S DISEASE RISK [PDF]

, 2019
Aseel Eid, Jason R. Richardson, Charles L. White, Dwight C. German   +3 more
openalex   +1 more source

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Three-Dimensional Amyloid-Beta PET Synthesis from Structural MRI with Conditional Generative Adversarial Networks [PDF]

arXiv
Motivation: Alzheimer's Disease hallmarks include amyloid-beta deposits and brain atrophy, detectable via PET and MRI scans, respectively. PET is expensive, invasive and exposes patients to ionizing radiation. MRI is cheaper, non-invasive, and free from ionizing radiation but limited to measuring brain atrophy.
arxiv  

Additional file 4 of Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein

, 2021
Amalia Tsolakidou, Ludwig Czibere, Benno Pütz, Dietrich Trümbach, Markus Panhuysen, Jan M. Deussing, Wolfgang Wurst, Inge Sillaber, Rainer Landgraf, Herta Flor, Theo Rein   +10 more
openalex   +2 more sources

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

New Aspects of Analyzing Amyloid Fibrils [PDF]

arXiv
This is a summary of mathematical tools we used in research of analyzing the structure of proteins with amyloid form \cite{xi2024Top}. We defined several geometry indicators on the discrete curve namely the hop distance, the discrete curvature and the discrete torsion.
arxiv  

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signaling [PDF]

, 2019
Claire S. Durrant, Karsten Ruscher, Olivia Sheppard, Michael P. Coleman, Ílknur Özen   +4 more
openalex   +1 more source

Dataset for the Amyloid-beta precursor protein antibody screening study

, 2023
Kathleen Southern
openalex   +2 more sources

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, EarlyView.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

A review of visualisations of protein fold networks and their relationship with sequence and function

Biological Reviews, Volume 98, Issue 1, Page 243-262, February 2023., 2023
ABSTRACT Proteins form arguably the most significant link between genotype and phenotype. Understanding the relationship between protein sequence and structure, and applying this knowledge to predict function, is difficult. One way to investigate these relationships is by considering the space of protein folds and how one might move from fold to fold ...
Janan Sykes, Barbara R. Holland, Michael A. Charleston   +2 more
wiley   +1 more source