The central benefit of physiologically induced ketogenic states
The Journal of Physiology, EarlyView.Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco +6 more
wiley +1 more source
Insights into Missense SNPs on Amyloidogenic Proteins. [PDF]
ProteomesGalanis FP +4 more
europepmc +1 more source
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]
, 2019 Bateman, Randall J.
core +1 more source
IC‐P‐010: Diagnostic utility of platelet amyloid precursor protein ratio, red blood cells and plasma beta amyloid (Aβ 1‐42) levels in late‐onset Alzheimer's disease [PDF]
, 2009 Ben S. Ashok +4 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland +4 more
wiley +1 more source
Association between Alzheimer's disease and <i>Porphyromonas gingivalis</i> products in murine models: A systematic review. [PDF]
World J Biol ChemOchoa KL +5 more
europepmc +1 more source
P1‐363: MONITORING THE SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA (SAPPA) AND BETA (SAPPB) FRAGMENTS IN PLASMA AND CSF FROM HEALTHY INDIVIDUALS TREATED WITH BACE INHIBITOR AZD3293 IN A MULTIPLE ASCENDING DOSE STUDY: PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATE [PDF]
, 2014 Kina Höglund +10 more
openalex +1 more source
Amyloid β alters vascular CaV1.2 channel spatiotemporal properties
The Journal of Physiology, EarlyView.Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor +5 more
wiley +1 more source
Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li +8 more
wiley +1 more source
The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey [PDF]
, 2017 Bateman, Randy J, et al,
core +2 more sources