Results 211 to 220 of about 94,035 (378)

Apolipoprotein E and Alzheimer’s disease: The influence of apolipoprotein E on amyloid- and other amyloidogenic proteins [PDF]

, 2017
Agosta, Alata, Albert A. Davis, Aleshkov, Allen, Alzheimer, Anderson, Atagi, Bailey, Bales, Bales, Bales, Basak, Bateman, Beffert, Beffert, Beffert, Bell, Bell, Benilova, Benjamin, Bernardi, Bertram, Bien-Ly, Bien-Ly, Biere, Brecht, Brunden, Bu, Caselli, Castellano, Castellano, Cedazo-Mínguez, Cheng, Cirrito, Cirrito, Cole, Cooper, Corder, Corder, Cotman, David M. Holtzman, de la Torre, Deane, Deane, DeMattos, Drory, Emamzadeh, Engelborghs, Esparza, Evans, Fabre, Fagan, Fagan, Farrer, Fryer, Fryer, Funato, Gallardo, Gallyas, Games, Gao, Garai, Govone, Greenberg, Grehan, Guerreiro, Gustafson, Halliday, Hardy, Harris, Harris, Heinonen, Hirsch-Reinshagen, Hirsch-Reinshagen, Holtzman, Holtzman, Holtzman, Holtzman, Hone, Hong, Hu, Huang, Huang, Huang, Hughes, Irizarry, Irwin, Irwin, Irwin, Iwai, Jakes, Jarrett, Jason D. Ulrich, Jellinger, Ji, Jiang, Jonsson, Josephs, Kanekiyo, Kehoe, Kim, Kim, Kim, Klunk, Klunk, Koistinaho, Koldamova, Korczyn, Kotzbauer, Lacomblez, LaDu, LaDu, Lashuel, Lee, Li, Li, Li, Li, Liao, Lill, Lippa, Liu, Liu, Ma, Mahley, Mahley, Mak, Mandrekar, Marchesi, Marder, Martin, Masliah, Mathis, Mattila, Mauch, McKee, Mikolaenko, Morris, Mui, Nalivaeva, Namba, Narita, Nathan, Nelson, Nielsen, Ohm, Panegyres, Paresce, Paresce, Pfeifer, Pfrieger, Pitas, Poirier, Praline, Rebeck, Rebeck, Reiman, Riemenschneider, Rockenstein, Roses, Roychaudhuri, Saavedra, Sabbagh, Saito, Sanan, Schmechel, Shaffer, Shibata, Siderowf, Srinivasan, Strittmatter, Strittmatter, Strittmatter, Sullivan, Sunderland, Szaruga, Tamamizu-Kato, Tesseur, Thal, Theendakara, Tien-Phat V. Huynh, Tiraboschi, Tokuda, Tsuang, Ulrich, Van Gool, van Horssen, Verghese, Wahrle, Wahrle, Wakabayashi, Wang, Watanabe, Wilson, Wisniewski, Wisniewski, Withers, Wood, Wyss-Coray, Yang, Ye, Yeh, Yuan, Zerbinatti, Zhang, Zhang, Zlokovic   +207 more
core   +2 more sources

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition. [PDF]

Nat Commun
Kim JP, Jung SH, Jang B, Cho M, Song M, Kim J, Kim B, Lee H, Shin D, Lee EH, Jang H, Kim BH, Ham H, Kim D, Raj T, Cruchaga C, Kim HJ, Na DL, Seo SW, Won HH.   +19 more
europepmc   +1 more source

Effect of the beta secretase-1 inhibitor on the amyloid C-terminal fragment of amyloid precursor protein processing in a hyperphosphorylated tau rat model

, 2014
H.Y. Chen, L Wang, J.F. Liu, W.Z. Wang, Chunjiang Yu   +4 more
openalex   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, EarlyView.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA‐miRNA network

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5779-5793, December 2022., 2022
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment and abnormal mental behaviour. There is currently no effective cure. The development of early diagnostic markers and the mining of potential therapeutic targets are one of the important strategies.
Zhi‐Hang Huang, Hai Wang, Dong‐Mei Wang, Xiu‐Yun Zhao, Wen‐Wen Liu, Xin Zhong, Dong‐Mei He, Ben‐Rong Mu, Mei‐Hong Lu   +8 more
wiley   +1 more source

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss. [PDF]

Alzheimers Dement
Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL.   +13 more
europepmc   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers

Journal of Neurochemistry, Volume 164, Issue 1, Page 57-76, January 2023., 2023
A genome‐scale model network was built for Alzheimer's disease (AD) using data from publicly available genome‐wide association studies in humans, and transcriptomics and proteomics data from brain tissue from mouse models of AD. The derived network was characterized by gene ontology, transcription factor analysis, and pathway and cell‐type enrichment ...
Monica Emili Garcia‐Segura, Brenan R. Durainayagam, Sonia Liggi, Gonçalo Graça, Beatriz Jimenez, Abbas Dehghan, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Julian L. Griffin   +9 more
wiley   +1 more source