Results 281 to 290 of about 94,035 (378)

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Tripeptides inhibit dual targets AChE and BACE-1: a computational study. [PDF]

RSC Adv
Do AT, Nguyen TH, Pham MQ, Nguyen HT, Long NP, Vu VV, Phung HTT, Ngo ST.   +7 more
europepmc   +1 more source

Perinatal asphyxia and Alzheimer's disease: is there a correlation? [PDF]

Front Pediatr
Arruda BP, Martins PP, Kihara AH, Takada SH.   +3 more
europepmc   +1 more source

Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart.

, 1993
T V Ramabhadran, Sam Gandy, Jorge Ghiso, Andrew J. Czernik, Douglas K. Ferris, R Bhasin, D Goldgaber, B Frangione, Paul Greengard   +8 more
openalex   +1 more source

Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, EarlyView.
The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley   +1 more source

Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease. [PDF]

Sci Rep
Amrutha S, Abhinand CS, Upadhyay SS, Parvaje R, Prasad TSK, Modi PK.   +5 more
europepmc   +1 more source

Amyloid Beta Precursor Protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)

Dennis E. M. de Bakker, Mihaela Mihaljević, Kunal Gharat, Yasmin Richter, Frauke van Bebber, Lisa Adam, Farzana Shamim-Schulze, Oliver Ohlenschläger, Martin Bens, Emilio Cirri, Adam Antebi, Ivan Matić, Anja Schneider, Bettina Schmid, Janine Kirstein, Dario Riccardo Valenzano   +15 more
openalex   +1 more source

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer's Disease Model. [PDF]

Biomolecules
Ando K, Kosa AC, Mehadji Y, Lasri H, Lopez-Gutierrez L, Quintanilla-Sánchez C, Aydin E, Doeraene E, Wathelet-Depauw A, Nagaraj S, Brion JP, Leroy K.   +11 more
europepmc   +1 more source

Alpha-, Beta-, and Gamma-Secretase, Amyloid Precursor Protein, and Tau Protein Genes in the Hippocampal CA3 Subfield in an Ischemic Model of Alzheimer’s Disease with Survival up to 2 Years

Stanisław J. Czuczwar, Janusz Kocki, Barbara Miziak, Jacek Bogucki, Anna Bogucka‐Kocka, Ryszard Pluta   +5 more
openalex   +2 more sources