Results 31 to 40 of about 94,035 (378)

Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein [PDF]

, 2008
BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ligands of the liver X receptors
Abraham, Carmela R., Chen, Ci-Di, Cordy, Joanna M., Guillily, Maria, Ray, William J., Seabrook, Guy R., Suon, Sokreine, Wolozin, Benjamin, Zerbinatti, Celina V.   +8 more
core   +4 more sources

The effect of stress on the expression of the amyloid precursor protein in rat brain [PDF]

, 2008
The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD).
Anderson, Balfour, Bartolomucci, Bradford, Budas, Caille, Caroline A. Stewart, Cleary, Coughlan, Coughlan, Csernansky, David J.K. Balfour, Deborah Robertson, Dong, Green, Jeong, Kieran C. Breen, Masuda, Mattson, McFarlane, Meziane, Rachel Sayer, Robertson, Sapolsky, Sapolsky, Sousa, Storey, Thornton, Vassar, Weiner, Yang   +30 more
core   +4 more sources

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease [PDF]

EBioMedicine, Elsevier, 2016, 9, pp.278-292, 2019
Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a 50% decrease in ADAM30 expression that ...
arxiv   +1 more source

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. [PDF]

Proceedings of the National Academy of Sciences, 1992
Altered proteolysis of the beta-amyloid precursor protein (beta APP) resulting in release of the approximately 40-residue amyloid beta-protein (A beta P) may be a seminal pathogenetic event in Alzheimer disease. Using region-specific beta APP antibodies, we searched for stable proteolytic intermediates containing the intact A beta P region in brain ...
Rajesh N. Kalaria, Ivan Lieberburg, Akira Tamaoka, Dennis J. Selkoe   +3 more
openaire   +3 more sources

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S., Chatterjee, U., Ganguly, G., Saso, L.   +3 more
core   +3 more sources

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
A tritiated tetrazine based on a phenyl/pyridyl core structure was successfully radiolabeled with NaBT4 by reducing an aldehyde moiety. The synthon was effectively employed to label an antibody in vitro with pretargeted autoradiography. Abstract Tetrazine (Tz)–trans‐cyclooctene (TCO) ligation is an ultra‐fast and highly selective reaction and it is ...
Natasha Shalina Radjani Bidesi, Umberto Maria Battisti, Sara Lopes van de Broek, Vladimir Shalgunov, Anne‐Mette Dall, Jesper Bøggild Kristensen, Dag Sehlin, Stina Syvänen, Gitte Moos Knudsen, Matthias Manfred Herth   +9 more
wiley   +1 more source

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

Frontiers in Neurology, 2017
Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin Xu   +9 more
doaj   +1 more source

Remodeling Alzheimer-amyloidosis models by seeding

Molecular Neurodegeneration, 2021
Alzheimer’s disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates.
Brittany S. Ulm, David R. Borchelt, Brenda D. Moore   +2 more
doaj   +1 more source

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Nature Communications, 2017
HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function ...
Qingqing Chai, Vladimir Jovasevic, Viacheslav Malikov, Yosef Sabo, Scott Morham, Derek Walsh, Mojgan H. Naghavi   +6 more
doaj   +1 more source

Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation [PDF]

, 2010
Background: Human β-amyloid, the main component in the neuritic plaques found in patients with Alzheimer's disease, is generated by cleavage of the β-amyloid precursor protein.
Ariel, Pablo, Federman, Maria Noel, Freudenthal, Ramiro A. M., Fustiñana, María Sol, Romano, Arturo Gabriel   +4 more
core   +3 more sources