PLoS ONE, 2009 BackgroundThe linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease.
Tomomi Kiyota +7 more
doaj +1 more source
Remodeling Alzheimer-amyloidosis models by seeding
Molecular Neurodegeneration, 2021 Alzheimer’s disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates.
Brittany S. Ulm +2 more
doaj +1 more source
Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. [PDF]
, 2015 Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease.
Goldstein, Lawrence SB +2 more
core +1 more source
HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
Nature Communications, 2017 HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function ...
Qingqing Chai +6 more
doaj +1 more source
The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease
Frontiers in Neurology, 2017 Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao +9 more
doaj +1 more source
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]
, 2011 Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L +3 more
core +2 more sources
Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit [PDF]
, 2012 Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration.
Busch, Stephanie +5 more
core +1 more source
Cytotoxic aggregation and amyloid formation by the myostatin precursor protein.
PLoS ONE, 2010 Myostatin, a negative regulator of muscle growth, has been implicated in sporadic inclusion body myositis (sIBM). sIBM is the most common age-related muscle-wastage disease with a pathogenesis similar to that of amyloid disorders such as Alzheimer's and ...
Carlene S Starck +1 more
doaj +1 more source
Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production [PDF]
Journal of Biological Chemistry, 2009 The amyloid precursor protein (APP) plays a central role in Alzheimer disease (AD) pathogenesis because sequential cleavages by beta- and gamma-secretase lead to the generation of the amyloid-beta (Abeta) peptide, a key constituent in the amyloid plaques present in brains of AD individuals.
Eggert, S. +3 more
openaire +3 more sources
New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]
, 2014 There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P. +2 more
core +3 more sources