Results 131 to 140 of about 249,317 (377)

SciAgents: Automating Scientific Discovery Through Bioinspired Multi‐Agent Intelligent Graph Reasoning

Advanced Materials, EarlyView.
The SciAgents AI model drives hypothesis generation by harnessing multi‐agent graph reasoning, extracting insights from knowledge graphs constructed from scientific papers. Each agent plays a specific role: the Ontologist defines concepts, the Scientists draft and refine proposals, and the Critic reviews.
Alireza Ghafarollahi, Markus J. Buehler
wiley   +1 more source

Associating Cognition With Amyloid Status Using Partially Ordered Set Analysis

Frontiers in Neurology, 2019
Background: The presence of brain amyloid-beta positivity is associated with cognitive impairment and dementia, but whether there are specific aspects of cognition that are most linked to amyloid-beta is unclear.
Sarah J.A. Carr, Sarah J.A. Carr, Judith Jaeger, Judith Jaeger, Shijia Bian, Ping He, Nancy Maserejian, Wenting Wang, Paul Maruff, Paul Maruff, Ahmed Enayetallah, Yanming Wang, Zhengyi Chen, Alan Lerner, Alan Lerner, Curtis Tatsuoka, Curtis Tatsuoka, Curtis Tatsuoka, Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing   +18 more
doaj   +1 more source

Sustainable Smart Packaging from Protein Nanofibrils

Advanced Materials, EarlyView.
Smart packaging can extend shelf life and improve food quality monitoring. This study introduces a novel smart packaging solution using amyloid fibrils and red radish anthocyanins to monitor seafood spoilage. These findings show that these films effectively indicate shrimp freshness and possess high antibacterial and antioxidant properties, offering a ...
Mohammad Peydayesh, Alan Kovacevic, Leah Hoffmann, Felix Donat, Ciatta Wobill, Laura Baraldi, Jiangtao Zhou, Christoph R. Müller, Raffaele Mezzenga   +8 more
wiley   +1 more source

The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep

Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Kelvin A. Yamada, Lin Xu, Steven N. Johnson, Susan Farr, William Banks   +5 more
core   +1 more source

Manipulating the Assembly and Architecture of Fibrillar Silk

Advanced Materials, EarlyView.
In this study, advanced in situ AFM, PiFM, and Cryo‐EM are leveraged to realize in situ observations of nucleation, growth, and degradation of silk nanofibrils. A clear picture of the assembly and structural evolution of regenerated silk nanofibrils is defined and demonstrates a novel strategy for manipulating their structure and properties, which ...
Chenyang Shi, Yuna Bae, Mingyi Zhang, James J. De Yoreo   +3 more
wiley   +1 more source

Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells

Molecular Therapy: Nucleic Acids, 2021
Deposition of amyloid beta plaques in adult rat or human brain is associated with increased production of proinflammatory cytokines by associated glial cells that are responsible for degeneration of the diseased tissue.
Dipayan De, Ishita Mukherjee, Subhalakshmi Guha, Ramesh Kumar Paidi, Saikat Chakrabarti, Subhas C. Biswas, Suvendra N. Bhattacharyya   +6 more
doaj  

Engineering of specific bacteriophages for early diagnosis of Alzheimer′s disease [PDF]

, 2016
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting a large proportion of the human population worldwide with great impact on social and economic level.
Kessels, Helmut W., Kluskens, Leon, Martins, Ivone M., Silva, Ana   +3 more
core  

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. [PDF]

, 1989
Dmitry Goldgaber, H. Harris, Timothy Hla, T Maciag, Robert Donnelly, J. Steven Jacobsen, Michael P. Vitek, D. C. Gajdusek   +7 more
openalex   +1 more source