Results 271 to 280 of about 249,317 (377)

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

Circular RNAs, miRNAs, and Exosomes: Their Roles and Importance in Amyloid-Beta and Tau Pathologies in Alzheimer's Disease. [PDF]

Neural Plast
Pala M, Yilmaz SG.
europepmc   +1 more source

Chemical Evolution of Early Macromolecules: From Prebiotic Oligopeptides to Self‐Organizing Biosystems via Amyloid Formation

Chemistry – A European Journal, EarlyView.
APR‐A, an aggregation‐prone oligopeptide, can convert into APR‐B through distinct mutational pathways—some exclusively forming insoluble amyloid‐like peptides, others yielding water‐soluble, non‐aggregating monomers. These orthogonal pathways in chemical evolution may have driven macromolecular assembly under prebiotic Earth conditions, potentially ...
Fruzsina Bencs, Nóra Taricska, Zsolt Dürvanger, Dániel Horváth, Zsolt Fazekas, Vince Grolmusz, Viktor Farkas, András Perczel   +7 more
wiley   +1 more source

Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus. [PDF]

Neuropsychopharmacol Rep
Al-Kuraishy HM, Sulaiman GM, Mohammed HA, Dawood RA, Albuhadily AK, Al-Gareeb AI, Abomughaid MM, Klionsky DJ.   +7 more
europepmc   +1 more source

Hybrid pH Responsive Supramolecular Polymers Through the Combination of the Ureido–Pyrimidinone Motif with β‐Sheet Peptide Sequences

Chemistry – A European Journal, EarlyView.
The combination of the ureido–pyrimidinone motif with two different β‐sheet peptide sequences yielded supramolecular structures with significantly different morphologies in water. The resulting supramolecular nanostructures showed structural stability between pH = 5 and 9, while precipitation occurred at pH = 3.0 and random coil formation at pH 12 ...
Riccardo Bellan, David Attia, Marcel H. P. van Genderen, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Erratum: Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist. [PDF]

J Korean Soc Radiol
Jeong SY, Suh CH, Lim JS, Choi Y, Kim HS, Kim SJ, Lee JH.   +6 more
europepmc   +1 more source

Constant pH Molecular Dynamics Simulation of pH Effects on Amyloid‐β Structure, Dynamics and Metal‐Binding

Chemistry – A European Journal, Accepted Article.
We report the first molecular dynamics simulations to examine the effect of pH on the structure, dynamics and metal‐binding ability of amyloid‐β, the peptide implicated in onset of Alzheimer's disease. We show that in the pH range of 6 to 8 only histidine residues show variable protonation, that predicted pKa values are in agreement with experimental ...
Thuraya Albrahadi, Christelle Hureau, James A. Platts   +2 more
wiley   +1 more source

Amyloid beta biomarker for dementia detection by hyperspectral ophthalmoscope images. [PDF]

Aging (Albany NY)
Ng YB, Sung SF, Nguyen HT, Liang SW, Tsao YM, Kao YH, Lin WS, Wang HC.   +7 more
europepmc   +1 more source

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

, 1997
Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa, Dao G. Pham, Nic Robinson, George M. Martin, Mark P. Mattson   +6 more
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