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The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions
Biomedicines, 2023 Amyloid beta peptide is an important biomarker in Alzheimer’s disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia.
Thomas Gabriel Schreiner +3 more
doaj +1 more source
Small-angle X-ray scattering characterization of a $$\beta $$ β -amyloid model in phantoms
BMC Research Notes, 2020 Objective We present a method to prepare an amyloid model at scalable quantities for phantom studies to evaluate small-angle x-ray scattering systems for amyloid detection. Two amyloid models were made from a plasma protein with and without heating. Both
Sophya Breedlove +3 more
doaj +1 more source
Differentiating amyloid beta spread in autosomal dominant and sporadic Alzheimer\u27s disease [PDF]
, 2022 Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer\u27s disease and autosomal-dominant Alzheimer\u27s disease, the latter of which is caused by mutations in genes involved in amyloid-beta processing.
Alzheimer’s Disease Neuroimaging Initiative, +12 more
core +3 more sources
Truncated and modified amyloid-beta species [PDF]
Alzheimer's Research & Therapy, 2014 AbstractAlzheimer’s disease pathology is closely connected to the processing of the amyloid precursor protein (APP) resulting in the formation of a variety of amyloid-beta (Aβ) peptides. They are found as insoluble aggregates in senile plaques, the histopathological hallmark of the disease. These peptides are also found in soluble, mostly monomeric and
Kummer, Markus P, Heneka, Michael T
openaire +4 more sources
Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
Frontiers in Aging Neuroscience, 2010 β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
doaj +1 more source
Acceleration of amyloid fibril formation by multichannel sonochemical reactor [PDF]
, 2021 Formation of amyloid fibrils of various amyloidogenic proteins is dramatically enhanced by ultrasound irradiation. For applying this phenomenon to the study of protein aggregation science and diagnosis of neurodegenerative diseases, a multichannel ultrasound irradiation system with individually adjustable ultrasound-irradiation conditions is necessary.
arxiv +1 more source
Beta-amyloid imaging in dementia [PDF]
Yeungnam University Journal of Medicine, 2018 Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia.
openaire +4 more sources
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? [PDF]
PLoS ONE, 2011 Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD).
Zareen Amtul +5 more
doaj +1 more source
Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]
, 2007 Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg +39 more
core +3 more sources
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
Molecular Neurodegeneration, 2009 Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and ...
O'Connor Peter B +4 more
doaj +1 more source