Results 31 to 40 of about 376,147 (348)

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]

, 2012
Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S., Handelsman, D.J., Harvey, A.R., Martins, R.N.   +3 more
core   +2 more sources

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]

, 2009
Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core   +2 more sources

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice [PDF]

, 2005
Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in ...
Avila, J. (Jesús), Cabodevilla, F. (Felipe), Catena, S. (Silvia), Cuadrado-Tejedor, M. (Mar), Ferrer, I. (Isidro), Gich, I. (Ignasi), Gomez-Isla, T. (Teresa), Lim, F. (Filip), Moran, M.A. (María Asunción), Nieto, M. (María), Ortiz, L. (Lourdes), Perez, M. (Mar), Perez-Mediavilla, L.A. (Luis Alberto), Puig, B. (Berta), Ramos, P. (Pilar), Ribe, E. (Elena M.), Samaranch, L. (Lluis), Sanchez, B. (Belén), Sesma, T. (Teresa)   +18 more
core   +1 more source

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

NeuroImage: Clinical, 2019
Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks.
F.C. Quevenco, S.J. Schreiner, M.G. Preti, J.M.G. van Bergen, T. Kirchner, M. Wyss, S.C. Steininger, A. Gietl, S.E. Leh, A. Buck, K.P. Pruessmann, C. Hock, R.M. Nitsch, A. Henning, D. Van De Ville, P.G. Unschuld   +15 more
doaj   +1 more source

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

BMC Neuroscience, 2006
Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean, Irwin Ronald W, Chen Shuhua, Nilsen Jon, Brinton Roberta   +4 more
doaj   +1 more source

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity

Molecular Brain, 2020
Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable
Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma   +5 more
doaj   +1 more source

The Contribution of S100B Suppression by Arundic Acid to the Inhibition of the Glio-Toxicity Induced by Beta-Amyloid in an Astrocytes Culture [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: It has been shown that glial activation has important role in the pathophysiology of Alzheimer’s disease. S100B is an astrocyte specific factor with deleterious effects on the neuronal and non-neuronal cells in the central nervous
Mahshid Hosseini, Mojtaba Keshavarz, Mahmood Vessal   +2 more
doaj  

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source