Results 31 to 40 of about 1,464,719 (336)
Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]
PLoS ONE, 2016 Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal +2 more
doaj +1 more source
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core +2 more sources
Neurotoxicity of .BETA.-amyloid.
Folia Pharmacologica Japonica, 2000 Recent observations on the neurotoxicity of beta-amyloid have been reviewed and possible roles of racemization of beta-amyloid are discussed. beta 1-40, beta 25-35 and D-Ser26 beta 25-35 (all HCl salt forms), but not commercially available beta 1-40 (TFA salt form), take the beta-structure within few hours in PBS, form fibrils, exert toxic effects on ...
I, Kaneko, T, Kubo, K, Morimoto
openaire +3 more sources
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]
, 2012 Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S. +3 more
core +2 more sources
Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Cells, 2019 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and ...
P. Hemachandra Reddy, D. Oliver
semanticscholar +1 more source
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The accumulation of amyloid β (Aβ) in the brain appears to be a necessary event in the pathogenesis of Alzheimer’s disease (AD). However, processes linked to the endogenous regulation of Aβ production are still not completely understood ...
Hao Wang +5 more
semanticscholar +1 more source
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Nature Communications, 2019 Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine.
I. Javed +11 more
semanticscholar +1 more source
Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice [PDF]
, 2005 Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in ...
Avila, J. (Jesús) +18 more
core +1 more source
Amyloid Beta and MicroRNAs in Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Alzheimer’s disease (AD) is a progressive mental illness characterized by memory loss and multiple cognitive impairments. In the last several decades, significant progress has been made in understanding basic biology, molecular mechanisms, and ...
N. Amakiri +3 more
semanticscholar +1 more source
NeuroImage: Clinical, 2019 Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks.
F.C. Quevenco +15 more
doaj +1 more source