Results 71 to 80 of about 249,317 (377)
Effect of goji berry on the formation of extracellular senile plaques of Alzheimer\u27s disease [PDF]
, 2021 BACKGROUND: Alzheimer\u27s disease (AD) is the most common neurodegenerative disease and a major source of morbidity and mortality. Currently, no therapy nor drug can cure or modify AD progression, but recent studies suggest that nutritional compounds in
Dong, Ke +4 more
core +1 more source
Amyloid beta-protein and lipid metabolism
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Lipids play an important part as risk or protective factors for Alzheimer's disease. This review summarizes the current findings in which lipids influence Alzheimer's disease and introduces the molecular mechanism how these lipids are linked to amyloid production.
Tobias Hartmann +2 more
openaire +3 more sources
Signaling interactions among neurons impact cell fitness and death in Alzheimer’s disease
Neural Regeneration Research, 2023 The pathology of Alzheimer’s disease involves a long preclinical period, where the characteristic clinical symptoms of the changes in the brain are undetectable. During the preclinical period, homeostatic mechanisms may help prevent widespread cell death.
Catherine Yeates +3 more
doaj +1 more source
The Budapest Amyloid Predictor and its Applications [PDF]
arXiv, 2020 The amyloid state of proteins is widely studied with relevancy in neurology, biochemistry, and biotechnology. In contrast with amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and anti-parallel $\beta$-sheets in a periodically repeated formation.
arxiv
Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease [PDF]
, 2017 Amyloid beta peptides (A\b{eta}), implicated in Alzheimers disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes changes in aging and AD. We designed multi component lipid models to mimic healthy and diseased states of the neuronal membrane. Using atomic force microscopy (AFM), Kelvin probe
arxiv +1 more source
Improved Prediction of Beta-Amyloid and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding [PDF]
arXiv, 2022 Background: Beta-amyloid (A$\beta$) plaques and tau protein tangles in the brain are the defining 'A' and 'T' hallmarks of Alzheimer's disease (AD), and together with structural atrophy detectable on brain magnetic resonance imaging (MRI) scans as one of the neurodegenerative ('N') biomarkers comprise the ''ATN framework'' of AD.
arxiv
Divergent Associations of Slow‐Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid‐Beta [PDF]
Objective: Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid-beta protein.
Bovy, Leonore +16 more
core +2 more sources
Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease
AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022 Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley +1 more source
Medical Sciences, 2018 The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving ...
Vladimir Volloch, Sophia Rits
doaj +1 more source
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression [PDF]
, 2023 Amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in Alzheimer's disease, though how this occurs is not well understood.
Aksman, Leon M +11 more
core