Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice [PDF]
, 2005 BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense
Dickey, Chad A +5 more
core +3 more sources
The Fuzzy Border between the Functional and Dysfunctional Effects of Beta-Amyloid: A Synaptocentric View of Neuron–Glia Entanglement [PDF]
, 2023 Francesca Fagiani +3 more
openalex +1 more source
Polarized secretion of beta-amyloid precursor proteinand amyloid beta-peptide in MDCK cells. [PDF]
Proceedings of the National Academy of Sciences, 1994 The beta-amyloid precursor protein (beta APP) is a widely expressed integral membrane protein that is proteolytically processed to yield several secreted derivatives, including soluble APP (APPs), the 4-kDa amyloid beta-peptide (A beta), and a related 3-kDa peptide (p3). To understand beta APP trafficking and processing, we analyzed the sorting of beta
C, Haass +3 more
openaire +2 more sources
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, EarlyView.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Sensors, 2018 Determination of the conformation (monomer, oligomer, or fibril) of amyloid peptide aggregates in the human brain is essential for the diagnosis and treatment of Alzheimer’s disease (AD).
Dahye Jeong +11 more
doaj +1 more source
Non-natural protein mimetics for the treatment of Alzheimer\u27s disease [PDF]
, 2011 Alzheimer\u27s disease (AD) is a slow degenerative disease that causes memory loss and eventually leads to death. AD is caused by the aggregation of the amyloid-beta protein, found on the outside of brain cells; once the amyloid-beta protein begins to ...
Brown, Jasmine +4 more
core +1 more source
Identification of Causal Relationship between Amyloid-beta Accumulation and Alzheimer's Disease Progression via Counterfactual Inference [PDF]
, 2023 Haixing Dai +14 more
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Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
Advanced Functional Materials, EarlyView.To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
wiley +1 more source
The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats
The Scientific World Journal, 2013 Oxidative stress is one of the pathological mechanisms responsible for the beta- amyloid cascade associated with Alzheimer’s disease (AD). Previous studies have demonstrated the role of carnosic acid (CA), an effective antioxidant, in combating oxidative
H. Rasoolijazi +5 more
doaj +1 more source
The immunotherapy of Alzheimer's disease
Immunity & Ageing, 2004 Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to enhance existing cerebral function in Alzheimer patients and not ...
Weksler Marc E
doaj +1 more source