Results 71 to 80 of about 1,464,719 (336)

Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives

Scientific Reports, 2017
The self-assembly of two derivatives of KLVFF, a fragment Aβ(16–20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1–42) is observed at sub-stoichiometric peptide concentrations ...
V. Castelletto, P. Ryumin, R. Cramer, I. Hamley, M. Taylor, D. Allsop, M. Reza, J. Ruokolainen, Thomas Arnold, D. Hermida-Merino, C. Garcia, M. C. Leal, E. Castaño   +12 more
semanticscholar   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]

, 2015
In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative, Braskie, Meredith N, Carmichael, Owen T, DeCarli, Charles, Scott, Julia A, Thompson, Paul M, Tosun, Duygu, Weiner, Michael   +7 more
core   +2 more sources

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism

BioMed Research International, 2018
Neuroinflammation has been observed in association with neurodegenerative diseases including Alzheimer's disease (AD). In particular, a positive correlation has been documented between neuroinflammatory cytokine release and the progression of the AD ...
F. Alasmari, Musaad A. Alshammari, A. Alasmari, Wael A Alanazi, Khalid Alhazzani   +4 more
semanticscholar   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Gold Nanoparticles Mediate Improved Detection of β-amyloid Aggregates by Fluorescence

Nanomaterials, 2020
The early detection of the amyloid beta peptide aggregates involved in Alzheimer’s disease is crucial to test new potential treatments. In this research, we improved the detection of amyloid beta peptide aggregates in vitro and ex vivo by fluorescence ...
Pedro Jara-Guajardo, Pablo Cabrera, Freddy Celis, Mónica Soler, Isadora Berlanga, Nicole Parra-Muñoz, Gerardo Acosta, Fernando Albericio, Fanny Guzman, Marcelo Campos, Alejandra Alvarez, Francisco Morales-Zavala, Marcelo J Kogan   +12 more
doaj   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Resveratrol and Amyloid-Beta: Mechanistic Insights

Nutrients, 2017
The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer’s disease (AD) has been proposed and examined in the AD research field. Scientists have focused on
Yongming Jia, Na Wang, Xuewei Liu
semanticscholar   +1 more source

An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco, Caterina Motta, Enrica Marchionni, Maria Rosaria D'Apice, Carlangelo Carrese, Giuseppe Novelli, Alessandro Martorana, Chiara Giuseppina Bonomi   +7 more
wiley   +1 more source

Hippocampal Beta-Amyloid Accumulation In Aluminium Chloride and D-Galactose-Induced Rats: Establishing a Nontransgenic Alzheimer’s Model

Journal of Pharmacy and Bioallied Sciences
Background: Alzheimer’s disease (AD) is characterized by tau protein aggregation and beta-amyloid (Aβ) plaques leading to progressive cognitive decline.
Thirupathirao Vishnumukkala, Samaila M. Chiroma, Saravanan Jagadeesan, Prarthana K. Gopalakrishna, Sreenivasulu Sura, Nurul H. Mohd Nor, Mohamad A. Mohd Moklas   +6 more
doaj   +1 more source