Results 251 to 260 of about 337,024 (290)

Genetics of the Alzheimer Amyloid Protein Precursor

1990
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of memory, reasoning, orientation, and judgment (Katzman, 1983). AD generally occurs as a sporadic disorder of unknown cause. However, a proportion of cases, which have been termed familial Alzheimer’s disease (FAD), are caused by a genetic defect that is
openaire   +3 more sources

Biological activities of amyloid precursor protein [PDF]

Acta Biologica Hungarica, 1998
Amyloid precursor protein (APP), a transmembrane glycoprotein, is the source of amyloidogenic β-amyloid peptide (βAP), the major constituent of the peptides deposited in senile plaques. Normallycleaved forms of APP exert potent neuroprotective action.
openaire   +1 more source

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Nature, 1991
A. Goate, M. Chartier-Harlin, M. Mullan, Jeremy S. Brown, F. Crawford, L. Fidani, L. Giuffra, A. Haynes, N. Irving, L. James, R. Mant, P. Newton, K. Rooke, P. Roques, C. Talbot, M. Pericak-Vance, A. Roses, R. Williamson, M. Rossor, M. Owen, J. Hardy   +20 more
semanticscholar   +1 more source

Posttranslational Modifications of the Amyloid Precursor Protein: Glycosylation

2003
Many studies have demonstrated the importance of amyloid precurser protein (APP) in the pathogenesis of Alzheimer's disease. Nonetheless, the exact mechanism by which APP contributes to the pathogenesis of Alzheimer's disease is still not clear. Because APP is a glycoprotein, and because glycosylation can be important in the cell biology of individual ...
Magda Stwora-Wojczyk, Tomasz Rozmyslowicz, Boguslaw S. Wojczyk, Chen Liu, Steven L. Spitalnik   +4 more
openaire   +3 more sources

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Nature, 1995
D. Games, David John Adams, Ree Alessandrini, R. Barbour, Patricia Borthelette, C. Blackwell, Tony Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-wood, K. Khan, Mike Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L. Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert, B. Snyder, F. Soriano, H. Tan, J. Vitale, S. Wadsworth, B. Wolozin, Jun Zhao   +33 more
semanticscholar   +1 more source

Signaling by β-Amyloid Precursor Protein

1998
The β-amyloid precursor protein (βAPP) is widely expressed in neurons and glial cells throughout the mammalian nervous system. APP is a large transmembrane glycoprotein having a single transmembrane domain, a large extracelluar N-terminus, and a short cytoplasmic C-terminus (Kang et al., 1987).
openaire   +2 more sources

Expression of amyloid precursor protein

Neurochemistry International, 1992
Henrik Gaardsvoll, Georgi Gegelashvili, Elisabeth Bock, Dorte Linnemann   +3 more
openaire   +2 more sources

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly  

The protein corona from nanomedicine to environmental science

Nature Reviews Materials, 2023
Assist Prof Morteza Mahmoudi, Markita P Landry, Roxana Coreas   +2 more
exaly