Results 91 to 100 of about 20,912 (233)

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment [PDF]

, 2010
Carrie McAllister, Jiangang Long, Adrienne Bowers, Aaron Walker, Philip Cao, Shin-Ichiro Honda, Nobuhiro Harada, Matthias Staufenbiel, Yong Shen, Rena Li   +9 more
openalex   +1 more source

A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch

Neurobiology of Disease, 2002
A novel presenilin 1 mutation, insR352, associated with a frontal temporal dementia phenotype has been identified (E. A. Rogaeva et al., 2001, Neurology 57, 621–625).
Zareen Amtul, Patrick A. Lewis, Sian Piper, Richard Crook, Matt Baker, Kirk Findlay, Andrew Singleton, Marion Hogg, Linda Younkin, Steven G. Younkin, John Hardy, Michael Hutton, Bradley F. Boeve, David Tang-Wai, Todd E. Golde   +14 more
doaj   +1 more source

Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein [PDF]

, 2010
Can Zhang, Andrew Browne, Daniel D. Child, Jason DiVito, Jesse A. Stevenson, Rudolph E. Tanzi   +5 more
openalex   +1 more source

Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 [PDF]

, 2001
Elvira Lopez‐Perez, Yue Zhang, Stuart J. Frank, John W.M. Creemers, Nabil G. Seidah, Frédéric Checler   +5 more
openalex   +1 more source

Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production [PDF]

, 2007
Xiangyuan He, Kathleen Cooley, Charlotte Hiu-Yan Chung, Nassrin Dashti, Jordan Tang   +4 more
openalex   +1 more source

The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase

Frontiers in Bioscience-Landmark
Background: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP).
Yuan Li, Hejie Li, Wenping Liang, Yu Li, Zhe Wang   +4 more
doaj   +1 more source

Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid β Protein Production via the β-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling [PDF]

, 2005
Il‐Sang Yoon, Claus U. Pietrzik, David E. Kang, Edward H. Koo   +3 more
openalex   +1 more source

The Role of Presenilin-1 in the γ-Secretase Cleavage of the Amyloid Precursor Protein of Alzheimer's Disease [PDF]

, 2000
Jean‐Noël Octave, Rachid Essalmani, Bernadette Tasiaux, Jean Ménager, Christian Czech, Luc Mercken   +5 more
openalex   +1 more source

Secretase promotes AD progression: simultaneously cleave Notch and APP

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang, Jing-Yi Zhang, Mei Feng, Kuo Yao, Yue-Yang Liu, Ming-Sheng Zhou, Hui Jia, Hui Jia   +7 more
doaj   +1 more source

Activity of α‐Secretase as the Common Final Effector of Protein Kinase C‐Dependent and ‐Independent Modulation of Amyloid Precursor Protein Metabolism [PDF]

, 1999
Marco Racchi, Daniela C. Solano, M. Sironi, Stefano Govoni   +3 more
openalex   +1 more source