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How Do Amyloid Pathology and Aberrant Neuronal Activity Disrupt Plasticity and Memory in Alzheimer's Disease? [PDF]

Neuroscientist
Subramanian J.
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Targeting Amyloid-β Proteins as Potential Alzheimer's Disease Therapeutics: Anti-Amyloid Drug Discovery, Emerging Therapeutics, Clinical Trials and Implications for Public Health. [PDF]

Pharmaceuticals (Basel)
Abduljawad AA, Alkinani KB, Zaakan A, AlGhamdi AS, Hamdoon AAE, Alshanbari BH, Alshehri AA, Alluhaybi BB, Alqashi SOI, Abduljawad RA.   +9 more
europepmc   +1 more source

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Successive cleavage of β-amyloid precursor protein by γ-secretase

Seminars in Cell & Developmental Biology, 2020
γ-Secretase is a multimeric aspartyl protease that cleaves the membrane-spanning region of the β-carboxyl terminal fragment (βCTF) generated from β-amyloid precursor protein. γ-Secretase defines the generated molecular species of amyloid β-protein (Aβ), a critical molecule in the pathogenesis of Alzheimer's disease (AD).
Satoru, Funamoto, Shinji, Tagami, Masayasu, Okochi, Maho, Morishima-Kawashima   +3 more
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ADAMs family members as amyloid precursor protein α‐secretases

Journal of Neuroscience Research, 2003
AbstractIn the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid‐β peptide. The large ectodomain released from the cell surface by the action of α‐secretase has several neuroprotective properties.
Allinson, Tobias M. J., Parkin, Edward T., Turner, Anthony J., Hooper, Nigel M.   +3 more
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Iron Levels Modulate α‐Secretase Cleavage of Amyloid Precursor Protein

Journal of Neurochemistry, 1995
Abstract: The amyloid precursor protein (APP) is a membrane‐spanning glycoprotein that is the source of βA4 peptides, which aggregate in Alzheimer's disease to form senile plaques. APP is cleaved within the βA4 sequence to release a soluble N‐terminal derivative (APPsol), which has a wide range of trophic and protective functions.
S, Bodovitz, M T, Falduto, D E, Frail, W L, Klein   +3 more
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β-Secretase Processing of the Alzheimer's Amyloid Protein Precursor (APP)

Journal of Molecular Neuroscience, 2003
An integral membrane aspartyl protease, BACE, is responsible for beta-secretase processing of the beta-amyloid precursor protein (APP) to the large secreted sAPPbeta and membrane-bound CTFbeta of 99 residues. CTFbeta is subsequently cleaved within the membrane by gamma-secretase to the amyloid beta protein (Abeta) that is deposited in the Alzheimer's ...
Laura, Marlow, Melissa, Cain, Miguel A, Pappolla, Kumar, Sambamurti   +3 more
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Recognition of the amyloid precursor protein by human γ-secretase

Science, 2019
The machinery behind amyloid peptides β-Amyloid peptides, which are derived from amyloid precursor protein (APP), form the plaques in the brain that are characteristic of Alzheimer's disease. Zhou et al.
Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi   +5 more
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