Results 201 to 210 of about 20,912 (233)

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

Experimental Brain Research, 2011
Alzheimer's disease causing mutations in the amyloid precursor protein (APP) or in the Presenilin 1 (PS1) or Presenilin 2 (PS2) genes increase the production of amyloid peptides (Aβ) that precipitate in amyloid plaques. Since amyloid plaques are also a prominent feature of sporadic Alzheimer's disease (AD), abnormal proteolysis of APP and the ...
Johannes, Prox, Andrea, Rittger, Paul, Saftig   +2 more
openaire   +2 more sources

ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

Molecular and Cellular Neuroscience, 2000
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's disease (AD). We and others have recently reported the identification and characterisation of an aspartic proteinase, Asp2 (BACE), as beta ...
I, Hussain, D J, Powell, D R, Howlett, G A, Chapman, L, Gilmour, P R, Murdock, D G, Tew, T D, Meek, C, Chapman, K, Schneider, S J, Ratcliffe, D, Tattersall, T T, Testa, C, Southan, D M, Ryan, D L, Simmons, F S, Walsh, C, Dingwall, G, Christie   +18 more
openaire   +2 more sources

Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase

2003
Human genetic studies suggest decreasing amyloid peptide (Aβ) levels in the brain could alter the course of Alzheimer's disease (AD) (1 -4). Proteolytic cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β- and γ-cleavages at the amino and carboxyl termini of Aβ produce amyloidogenic peptides; in contrast, α-cleavage ...
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Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases

Amyloid, 1998
Proteolytic cleavage of the amyloid precursor protein (A beta PP) results in the generation of the amyloidogenic fragment known as amyloid beta peptide (A beta). Deposition of A beta in the brain parenchyma and cerebrovasculature is a feature of Alzheimer's disease (AD). To date, the process whereby A beta is generated and deposited remains unclear. We
E R, Simons, D C, Marshall, H J, Long, K, Otto, A, Billingslea, H, Tibbles, J, Wells, P, Eisenhauer, R E, Fine, D H, Cribbs, T A, Davies, C R, Abraham   +11 more
openaire   +2 more sources

Angiotensin-converting enzyme and the amyloid precursor protein secretases

Biochemical Society Transactions, 1999
N M, Hooper, S, Parvathy, E H, Karran, A J, Turner   +3 more
openaire   +2 more sources

Molecular characterisation of the alzheimer's amyloid precursor protein secretases

Biochemical Society Transactions, 1998
S L, Houldsworth, A J, Trew, N M, Hooper, A J, Turner   +3 more
openaire   +2 more sources

Specificity of the Alzheimer's amyloid precursor protein α-secretase

Trends in Biochemical Sciences, 1995
N M, Hooper, A J, Turner
openaire   +2 more sources

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly  

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Phuong H Nguyen, Ayyalusamy Ramamoorthy, Bikash Sahoo   +2 more
exaly