Results 71 to 80 of about 14,023 (271)

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]

, 2005
In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc, Dermaut, Bart, Kumar-Singh, Samir, Rademakers, Rosa, Theuns, Jessie, Van Broeckhoven, Christine   +5 more
core   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Intracellular trafficking of the β-secretase and processing of amyloid precursor protein [PDF]

IUBMB Life, 2011
The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the β-amyloid peptide (Aβ) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Aβ is derived from the proteolytic processing of the amyloid precursor protein (APP).
Pei, Zhi, Pei Zhi Cheryl, Chia, Cheryl, Chia, Paul A, Gleeson   +3 more
openaire   +2 more sources

Single-Cell Detection of Secreted A  and sAPP  from Human IPSC-Derived Neurons and Astrocytes [PDF]

, 2015
Secreted factors play a central role in normal and pathological processes in every tissue in the body. The brain is composed of a highly complex milieu of different cell types and few methods exist that can identify which individual cells in a complex ...
De Jager, P. L., Gierahn, Todd Michael, Liao, M.-C., Love, John C, Muratore, C. R., Srikanth, P., Sullivan, S. E., Young-Pearse, T. L.   +7 more
core   +1 more source

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

Neurobiology of Disease, 2005
In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Séverine Bégard, Hervé Drobecq, Antoine Ghestem, Marie-Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buée, André Delacourte, Nicolas Sergeant   +12 more
doaj   +1 more source

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains

Molecular Brain, 2021
Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits has been directly linked to altered generation
Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia, Deepak Nair   +5 more
doaj   +1 more source

Exposure to lead and incidence of Alzheimer's disease and all‐cause dementia in the United States

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Growing evidence suggests lead exposure may increase dementia risk, but evidence from human studies is limited. We investigated prospective associations between lead exposure and incident Alzheimer's disease (AD) and all‐cause dementia in nationally‐representative US populations.
Xin Wang, Kelly M. Bakulski, Erika Walker, Bhramar Mukherjee, Hiroko Dodge, Roger L. Albin, Henry L. Paulson, Sung Kyun Park   +7 more
wiley   +1 more source

Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

Neuropharmacology, 2014
Amyloid precursor protein (APP) shedding yields the Alzheimer's disease (AD)-related peptide amyloid β (Aβ) through β- and γ-secretase cleavage. Alternatively, α-secretase cleavage generates a soluble and neuroprotective fragment (sAPPα) while precludes the production of Aβ.
Durand, Daniela Elizabeth, Carniglia, Lila, Beauquis, Juan, Caruso, Carla Mariana, Saravia, Flavia Eugenia, Lasaga, Mercedes Isabel   +5 more
openaire   +3 more sources

Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease [PDF]

, 2012
BACKGROUND: Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD).
Angelyn Lao, Olaf Wolkenhauer, Thomas E Willnow, Vanessa Schmidt, Yvonne Schmitz   +4 more
core   +2 more sources