Results 21 to 30 of about 13,480 (279)
J Proteins Counteract Amyloid Propagation and Toxicity in Yeast
Biology, 2022 The accumulation of misfolded proteins as amyloids is associated with pathology in dozens of debilitating human disorders, including diabetes, Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Daniel C. Masison +2 more
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Amyloids assemble as part of recognizable structures during oogenesis in Xenopus
Biology Open, 2016 A hallmark of Alzheimer's, Huntington's and similar diseases is the assembly of proteins into amyloids rather than folding into their native state. There is an increasing appreciation that amyloids, under specific conditions, may be non-pathogenic.
Michael H. Hayes, Daniel L. Weeks
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Microbial amyloids in neurodegenerative amyloid diseases
The FEBS Journal, 2023 Human‐disease associated amyloidogenic proteins are not unique in their ability to form amyloid fibrillar structures. Numerous microbes produce amyloidogenic proteins that have distinct functions for their physiology in their amyloid form, rather than solely detrimental. Emerging data indicate associations between various microbial organisms, including
openaire +2 more sources
SynBio and the Boundaries between Functional and Pathogenic RepA-WH1 Bacterial Amyloids
mSystems, 2020 Amyloids are protein polymers that were initially linked to human diseases. Across the whole Tree of Life, many disease-unrelated proteins are now emerging for which amyloids represent distinct functional states.
Rafael Giraldo
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M60-like metalloprotease domain of the Escherichia coli YghJ protein forms amyloid fibrils. [PDF]
PLoS ONE, 2018 Amyloids are protein fibrils with a characteristic spatial structure. Amyloids were long perceived as the pathogens involved in a set of lethal diseases in humans and animals.
Mikhail V Belousov +9 more
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Recent High-Resolution Structures of Amyloids Involved in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2021 Amyloids are highly ordered aggregates composed of proteins or peptides. They are involved in several pathologies, including hallmark neurodegenerative disorders such as Alzheimer’s (AD) and Parkinson’s (PD).
Rodrigo Diaz-Espinoza
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Pharmacological Agents Targeting the Cellular Prion Protein
Pathogens, 2018 Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain ...
Maria Letizia Barreca +4 more
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Molecules, 2020 The term “amyloid” refers to proteinaceous deposits of peptides that might be generated from larger precursor proteins e.g., by proteolysis.
Kristina Endres
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Direct Identification of Functional Amyloid Proteins by Label-Free Quantitative Mass Spectrometry
Biomolecules, 2017 Functional amyloids are important structural and functional components of many biofilms, yet our knowledge of these fascinating polymers is limited to a few examples for which the native amyloids have been isolated in pure form.
Heidi N. Danielsen +6 more
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Viruses, 2019 The mechanism of prion strain diversity remains unsolved. Investigation of inheritance and diversification of protein-based pathogenic information demands the identification of the detailed structures of abnormal isoforms of the prion protein (PrPSc ...
Yuzuru Taguchi +2 more
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