Toxins, 2021 Pseudomonas aeruginosa is an opportunistic, Gram-negative pathogen and an important cause of hospital acquired infections, especially in immunocompromised patients. Highly virulent P.
Kierra S. Hardy +3 more
doaj +1 more source
The LBFGS Quasi-Newtonian Method for Molecular Modeling Prion AGAAAAGA Amyloid Fibrils [PDF]
, 2012 Experimental X-ray crystallography, NMR (Nuclear Magnetic Resonance) spectroscopy, dual polarization interferometry, etc are indeed very powerful tools to determine the 3-Dimensional structure of a protein (including the membrane protein); theoretical ...
Hou, Yating +4 more
core +3 more sources
Cold Spring Harbor Perspectives in Biology, 2019 When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire +3 more sources
Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?
Biomedicines, 2022 Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4 million individuals in 2021. It is primarily classified as an autoimmune disorder, where the pancreatic β-cells are unable to secrete sufficient insulin.
Aishwarya A. Makam +3 more
doaj +1 more source
Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs [PDF]
, 2016 Altres ajuts: MARATOTV3/2013/3930In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules.
Abasolo, Ibane +15 more
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Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins [PDF]
, 2012 The number of existing protein sequences spans a very small fraction of sequence space. Natural proteins have overcome a strong negative selective pressure to avoid the formation of insoluble aggregates.
Campen +25 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Functional characterization of TasA and TapA in the formation of the amyloid fiber in Bacillus subtilis [PDF]
, 2017 Introduction Functional amyloids are a very heterogeneous family of amyloid proteins widespread in nature, from humans to bacteria. Unlike their “pathogenic” relatives, implicated in several neurodegenerative diseases, functional amyloids play important
Conejero-Lara, Francisco +3 more
core
The proteostasis network and its decline in ageing
, 2019 Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core +1 more source
Profiling the serum protein corona of fibrillar human islet amyloid polypeptide [PDF]
, 2018 Amyloids may be regarded as native nanomaterials that form in the presence of complex protein mixtures. By drawing an analogy with the physicochemical properties of nanoparticles in biological fluids, we hypothesized that amyloids should form a protein ...
Davis, Thomas P. +10 more
core +2 more sources