Results 41 to 50 of about 14,195 (294)

The amyloid precursor protein: beyond amyloid.

Molecular neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Zheng H., Koo E.H.
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Interaction of Fibronectin With Semen Amyloids Synergistically Enhances HIV Infection [PDF]

, 2014
Semen harbors amyloids that enhance human immunodeficiency virus type 1 (HIV-1) infection. We set out to identify factors that bind these amyloids and to determine whether these factors modulate amyloid-mediated HIV-enhancing activity.
Roan, Nadia R, Witkowska, H Ewa, Chu, Simon, Greene, Warner C, Liu, Haichuan, Neidleman, Jason   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Aggregation in gut: on the link between neurodegeneration and bacterial functional amyloids

npj Biofilms and Microbiomes
Amyloids are insoluble protein aggregates with a cross-beta structure, which are traditionally associated with neurodegeneration. Similar structures, named functional amyloids, expressed mostly by microorganisms, play important physiological roles, e.g.,
Alicja W. Wojciechowska, Jakub W. Wojciechowski, Kinga Zielinska, Johannes Soeding, Tomasz Kosciolek, Malgorzata Kotulska   +5 more
doaj   +1 more source

Patterns of amyloid accumulation in amyloid-negative cases

Neurobiology of Aging, 2022
Introduction: Amyloid staging models showed that regional abnormality occurs before global positivity. Several studies assumed that the trajectory of amyloid spread is homogeneous, but clinical evidence suggest that it is highly heterogeneous. We tested whether different Aβ-patterns exist by applying a clustering on negative scans and investigating ...
Alchera, Nicola, Garibotto, Valentina, Tomczyk, Szymon, Treyer, Valerie, Hock, Christoph, Gietl, Anton F, Lövblad, Karl-Olof, Scheffler, Max, Chincarini, Andrea, Frisoni, Giovanni B, Ribaldi, Federica   +10 more
openaire   +4 more sources

Accumulation of storage proteins in plant seeds is mediated by amyloid formation.

PLoS Biology, 2020
Amyloids are protein aggregates with a highly ordered spatial structure giving them unique physicochemical properties. Different amyloids not only participate in the development of numerous incurable diseases but control vital functions in archaea ...
Kirill S Antonets, Mikhail V Belousov, Anna I Sulatskaya, Maria E Belousova, Anastasiia O Kosolapova, Maksim I Sulatsky, Elena A Andreeva, Pavel A Zykin, Yury V Malovichko, Oksana Y Shtark, Anna N Lykholay, Kirill V Volkov, Irina M Kuznetsova, Konstantin K Turoverov, Elena Y Kochetkova, Alexander G Bobylev, Konstantin S Usachev, Oleg N Demidov, Igor A Tikhonovich, Anton A Nizhnikov   +19 more
doaj   +1 more source

Trapping virus-loaded aerosols using granular material composed of protein nanofibrils and iron oxyhydroxides nanoparticles

Frontiers in Soft Matter, 2023
The ongoing COVID-19 pandemic has revealed that developing effective therapeutics against viruses might be outpaced by emerging variants, waning immunity, vaccine skepticism/hesitancy, lack of resources, and the time needed to develop virus-specific ...
Antonius Armanious, Heyun Wang, Peter A. Alpert, Chiara Medaglia, Mohammad Peydayesh, Arnaud Charles-Antoine Zwygart, Christian Gübeli, Stephan Handschin, Sreenath Bolisetty, Markus Ammann, Caroline Tapparel, Francesco Stellacci, Francesco Stellacci, Francesco Stellacci, Raffaele Mezzenga, Raffaele Mezzenga   +15 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source