Results 51 to 60 of about 13,480 (279)
The role of disorder in RNA binding affinity and specificity [PDF]
Open Biology, 2020 Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein
Nature CommunicationsReversible and irreversible amyloids are two diverging cases of protein (mis)folding associated with the cross-β motif in the protein folding and aggregation energy landscape.
Lukas Frey +13 more
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“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine
Molecules, 2020 Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans.
Sherin Abdelrahman +5 more
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Patterns of amyloid accumulation in amyloid-negative cases
Neurobiology of Aging, 2022 Amyloid staging models showed that regional abnormality occurs before global positivity. Several studies assumed that the trajectory of amyloid spread is homogeneous, but clinical evidence suggests that it is highly heterogeneous. We tested whether different amyloid-β (Aβ) patterns exist by applying clustering on negative scans and investigating their ...
Alchera, Nicola +10 more
openaire +4 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage
Scientific ReportsDespite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades.
Diego Alem +13 more
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Induction of cancer cell death by amyloids.
, 2019 The pathway of cell death induced by amyloids was analyzed by flow cytometry. Representative scatter plots showing Annexin V and PI staining of NB4 cells, I–necrosis (Annexin V-/PI+), II–late apoptosis (Annexin V+/PI+), III–early apoptosis (Annexin V+/PI-
Giedre Valiuliene (7372931) +7 more
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery
Molecules, 2019 Amyloids are self-perpetuating protein aggregates causing neurodegenerative diseases in mammals. Prions are transmissible protein isoforms (usually of amyloid nature).
Tatiana A. Chernova +2 more
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