Results 71 to 80 of about 13,480 (279)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Natural protective amyloids

, 2008
Amyloidoses are a group of diseases including neurodegenerative diseases like Alzheimer's disease and also type II diabetes, spongiform encephalopathies and many others, believed to be caused by protein aggregation and subsequent amyloid fibril ...
Iconomidou, V.A., Hamodrakas, S.J.
core   +1 more source

On Amyloid Protein [PDF]

Medical Humanities, 2017
I watch your eyes tracing my face. Furrowed brows suggest blurred image. Slow, slow, not in haste— Mine is a forgotten visage, Erased …
openaire   +2 more sources

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids [PDF]

Pathogenic protein aggregates, called amyloids, are etiological-ly relevant to various diseases, including neurodegenerative Alzheimer disease. Catalytic photooxygenation of amyloids, such as amyloid-β (Aβ), reduces their toxicity; however, the ...
Hiroki, Umeda, Motomu, Kanai, Daisuke, Yokogawa, Kayo, Suda, Shigehiro A., Kawashima, Harunobu, Mitsunuma, Yuki, Yamanashi   +6 more
core   +2 more sources

Structure, function and antagonism of semen amyloids [PDF]

, 2018
Amyloids in semen enhance HIV infection and promote clearance of defect sperm.
Roan, Nadia R, Annika Röcker, Yadav, Jay Kant, Fändrich, Marcus, Jan Münch, Nadia R. Roan, Röcker, Annika, Marcus Fändrich, Münch, Jan, Jay Kant Yadav   +9 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Biofilm-associated proteins: from the gut biofilms to neurodegeneration

Gut Microbes
Human microbiota form a biofilm with substantial consequences for health and disease. Numerous studies have indicated that microbial communities produce functional amyloids as part of their biofilm extracellular scaffolds.
Jaione Valle
doaj   +1 more source

Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons [PDF]

, 2020
Pseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal fluids of critically ill patients.
Balczon, Ron, Scott, Allison M., Jager, Alexandrea C., Stevens, Troy, Gwin, Meredith, Voth, Sarah, Lin, Mike T.   +6 more
core   +1 more source