Results 91 to 100 of about 13,480 (279)

Amyloid Assembly Endows Gad m 1 with Biomineralization Properties

Biomolecules, 2018
Acid proteins capable of nucleating Ca2+ and displaying aggregation capacity play key roles in the formation of calcium carbonate biominerals. The helix-loop helix EF-hands are the most common Ca2+-binding motifs in proteins. Calcium is bound by the loop
Milagros Castellanos, Almudena Torres-Pardo, Rosa Rodríguez-Pérez, María Gasset   +3 more
doaj   +1 more source

Hormone amyloids in sickness and in health

, 2013
Amyloids are highly ordered cross-β-sheet containing protein aggregates associated with several dozens diseases including Alzheimer's, Creutzfeldt-Jakob and Parkinson's disease, and are also associated with functional states such as hormone storage in ...
Martin Spiess, Roland Riek, Jonas Rutishauser, Nadezhda Nespovitaya, Nespovitaya, N., Spiess, M., Carolin Seuring, Rutishauser, J., Seuring, C., Riek, R.   +9 more
core   +1 more source

Interaction of microbial functional amyloids with solid surfaces

, 2021
Hypothesis: Self-assembling protein subunits hold great potential as biomaterials with improved functions. Among the self-assembled protein structures functional amyloids are promising unique properties such as resistance to harsh physical and chemical ...
Yuca, Esra, YÜCA YILMAZ, Esra, Kehribar, Ebru Sahin, Seker, Urartu Ozgur Safak   +3 more
core   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface

Frontiers in Immunology
C-reactive protein (CRP) protects mice during the initial stages of Streptococcus pneumoniae infection. In order to be protective against all stages of infection, we hypothesize that CRP binds to two different ligands on pneumococci.
Alok Agrawal, Donald N. Ngwa, J. Paul Simons, Sanjay K. Singh   +3 more
doaj   +1 more source

Modeling of molecular processes underlying Parkinson’s disease in cells of methylotrophic yeast Hansenula polymorpha

Біологічні студії, 2014
Abnormal oligomerisation and aggregation of the protein called alpha-synuclein (α-syn) are the key events in the pathogenesis of Parkinson’s disease (PD). Recent discoveries revealed cellular pathways that potentially relate neurodegenerative disease (ND)
I. O. Denega, N. I. Klymyshyn, N. O. Sybirna, O. V. Stasyk, O. G. Stasyk   +4 more
doaj   +1 more source

Amyloid and inflammation [PDF]

Proceedings of the National Academy of Sciences, 2013
Thirty human and 10 animal proteins form amyloid fibrils associated with codeposition of P-component (SAP), heparatan sulfate proteoglycans (HSPGs), certain apolipoproteins (e.g., ApoE), as well as other less well-defined “ground substances” that may mitigate fibrillogenesis and tissue-specific deposition in association with aging or disease.
openaire   +2 more sources

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source