Results 101 to 110 of about 13,480 (279)
Biological Amyloids Chemically Damage DNA [Elektronisk resurs]
Amyloid fibrils are protein polymers noncovalently assembled through beta-strands arranged in a cross-beta structure. Biological amyloids were considered chemically inert until we and others recently demonstrated their ability to catalyze chemical ...
Rehnberg, Nikita, +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão +5 more
wiley +1 more source
The activities of amyloids from a structural perspective.
, 2016 The aggregation of proteins into structures known as amyloids is observed in many neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of pairs of tightly interacting, many stranded and repetitive intermolecular β-sheets ...
Eisenberg DS, Riek R
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All‐Amyloid Functional Coacervates
Advanced Materials, EarlyView.This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi +4 more
wiley +1 more source
Biological Functions of Prokaryotic Amyloids in Interspecies Interactions: Facts and Assumptions
, 2020 Amyloids are fibrillar protein aggregates with an ordered spatial structure called “cross-β”. While some amyloids are associated with development of approximately 50 incurable diseases of humans and animals, the others perform various ...
Anton A. Nizhnikov +3 more
core +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Saponins Effect on Human Insulin Amyloid Aggregation
BiomoleculesThe misfolding and amyloid aggregation of proteins have been attracting scientific interest for a few decades, due to their link with several diseases, particularly neurodegenerative diseases. Proteins can assemble and result in insoluble aggregates that,
Eleonora Mari +6 more
doaj +1 more source
Inhibition of peptide aggregation by means of enzymatic phosphorylation
Beilstein Journal of Organic Chemistry, 2016 As is the case in numerous natural processes, enzymatic phosphorylation can be used in the laboratory to influence the conformational populations of proteins.
Kristin Folmert +5 more
doaj +1 more source
Host defense amyloids: Biosensors of the immune system?
There is considerable evidence showing that highly ordered aggregate structures known as amyloids carry out essential biological roles in species ranging from bacteria to humans.
Cornwall, G. A., Myers, Caitlyn,
core +1 more source