Results 141 to 150 of about 345,476 (333)

Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Colorectal cancer, a leading cause of death in the Western world, is increasingly affecting younger populations. The Warburg effect, characterized by enhanced lactate production, is a hallmark of this cancer type. Although 18F‐FDG PET‐CT is commonly used for diagnosis, MRI offers higher spatial and chemical resolution without the ...
Josh P. Peters, Hang Xiang, Charbel D. Assaf, Farhad Haj Mohamad, Philip Rosenstiel, Stefan Schreiber, Jan‐Bernd Hövener, Konrad Aden, Andrey N. Pravdivtsev   +8 more
wiley   +1 more source

Pasteur effect in leukocyte energy metabolism of patients with mild, moderate, and severe COVID-19

Türk Biyokimya Dergisi
The Pasteur effect in cellular energy metabolism is defined as the switch to anaerobic glycolysis due to alterations in ambient oxygen concentration or inhibition of the electron transport chain (ETC) and oxidative phosphorylation.
Ortatatli Mesut, Sengul Goksemin Fatma, Fatsa Tugba, Sertoglu Erdim, Boyunaga Hakan, Kenar Levent   +5 more
doaj   +1 more source

Stealth Drug Delivery of Mouse Serum Albumin‐Coated Paclitaxel‐Loaded Gelatin Nanoparticles for Targeted Cancer Therapy in Mice

Nano Select, EarlyView.
Our study presents a novel approach to localized cancer therapy by developing mouse serum albumin (MSA)‐coated paclitaxel (PTX)‐loaded gelatin nanoparticles (MSA@PTX‐loaded GNPs) as a stealth drug delivery system. Given the challenges of nanoparticle‐based chemotherapy, including rapid opsonization and limited drug accumulation at tumor sites, our work
Md. Annur Sadman, Forhad Bin Faruk, Arifur Rahman Nibir, Tasmihaw Tanha Oishi, Nazifa Siraj Katha, Md. Mujahidul Islam Chowdhury, Rifa Tasfia Faiza, Nishat Tasnim, Saoda Islam Aurni, Tahmina Yasmin, Shazid Md. Sharker   +10 more
wiley   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Enforcing ATP hydrolysis enhanced anaerobic glycolysis and promoted solvent production in Clostridium acetobutylicum. [PDF]

Microb Cell Fact, 2021
Dai Z, Zhu Y, Dong H, Zhao C, Zhang Y, Li Y.   +5 more
europepmc   +1 more source

Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.

PLoS Computational Biology
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional.
Pahala Gedara Jayathilake, Pedro Victori, Clara E Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian L Harris, Karl J Morten, Francesca M Buffa   +9 more
doaj   +1 more source

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus)

Integrative Zoology, EarlyView.
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang, Yingying Zhang, Zhuohang Li, Tianyi Liu, Jianping He, Jingang Li   +5 more
wiley   +1 more source

Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis. [PDF]

Antioxidants (Basel), 2021
Huang YC, Cheng ML, Tang HY, Huang CY, Chen KM, Wang JS.   +5 more
europepmc   +1 more source

Immunometabolic effects of lactate on humoral immunity in healthy individuals of different ages

Nature Communications
Aging is characterized by chronic systemic inflammation and metabolic changes. We compare the metabolic status of B cells from young and elderly donors and found that aging is associated with higher oxygen consumption rates, and especially higher ...
Maria Romero, Kate Miller, Andrew Gelsomini, Denisse Garcia, Kevin Li, Dhananjay Suresh, Daniela Frasca   +6 more
doaj   +1 more source

Comparative Decay Dynamics and Detectability of eDNA and eRNA in Connected and Isolated Freshwater Mesocosms Using Digital PCR

Molecular Ecology Resources, EarlyView.
ABSTRACT Efficient use of environmental nucleic acids (eNAs) in freshwater biodiversity monitoring requires understanding their degradation and detectability in interconnected ecosystems. We employed a novel field‐scale assay to compare environmental DNA (eDNA) and environmental RNA (eRNA) decay rates and detectability across four genetic markers (16S,
Wendy B. Morgado‐Gamero, Orianne Tournayre, Melania E. Cristescu   +2 more
wiley   +1 more source