Results 151 to 160 of about 341,458 (322)

Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age

Aging Cell, EarlyView.
Human skin fibroblasts in vitro preserve the memory of age and health. ABSTRACT Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite ...
Chloé Brodeau, Camille Joly, Anaïs Chekroun, Jean Nakhle, Vincent Blase, Nicolas Espagnolle, Cédric Dray, Armelle Yart, Valérie Planat, Margot Tertrais, Julien Fassy, Sophie Guyonnet, Wan‐Hsuan Lu, Philipe de Souto Barreto, Olivier Teste, Marie Tremblay‐Franco, Kamaryn T. Tanner, Alan A. Cohen, Audrey Carriere, Louis Casteilla, Isabelle Ader, IHU HealthAge/Open Science group   +21 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Advancements in research on lactate dehydrogenase A in urinary system tumors

BMC Urology
Tumors of the urinary system, such as prostate cancer, bladder cancer, and renal cell carcinoma, are among the most prevalent types of tumors. They often remain asymptomatic in their early stages, with some patients experiencing recurrence or metastasis ...
Zhiyuan Zhuo, Yu Wang, Yifan Xu
doaj   +1 more source

Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer

JID Innovations, 2021
Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased production of L-lactate.
Anushka Dikshit, Junqi Lu, Amy E. Ford, Simone Degan, Yingai J. Jin, Huiying Sun, Amanda Nichols, April K.S. Salama, Georgia Beasley, David Gooden, Jennifer Y. Zhang   +10 more
doaj  

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Stimulation of glycolysis in anaerobic elongation of pondweed (Potamogeton distinctus) turions [PDF]

, 2002
Takuya Sato
openalex   +1 more source

TRANS-VALVULAR UNLOADING REDUCES ANAEROBIC GLYCOLYSIS BEFORE REPERFUSION AND PRESERVES ENERGY SUBSTRATE UTILIZATION AFTER REPERFUSION IN MODELS OF ACUTE MYOCARDIAL INFARCTION

, 2022
Lija Swain, Xiaoying Qiao, Kay Everett, Shreyas Bhave, Lara Reyelt, Tejasvi Aryaputra, William Surks, Siya Goel, Elric Zweck, Nikolaos Diakos, Navin K. Kapur   +10 more
openalex   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

ANAEROBIC GLYCOLYSIS IN NERVOUS TISSUE

Journal of Biological Chemistry, 1945
John M. Reiner, Harland G. Wood, Merton F. Utter   +2 more
openaire   +2 more sources

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source