Results 41 to 50 of about 4,121 (265)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy

Sensors, 2016
This paper presents a multi-channel dual-mode CMOS analogue front-end (AFE) for electrochemical and bioimpedance analysis. Current-mode and voltage-mode readouts, integrated on the same chip, can provide an adaptable platform to correlate single-cell ...
Virgilio Valente, Andreas Demosthenous
doaj   +1 more source

An 8‐bit digital‐to‐time converter with pre‐skewing and time interpolation

IET Circuits, Devices and Systems, 2021
This study presents an 8‐bit delay line digital‐to‐time converter (DTC) with pre‐skewing and digital time interpolation. Pre‐skewing that lowers the per‐stage‐delay of delay lines beyond that set by the chosen technology is investigated.
Daniel Junehee Lee, Fei Yuan, Gul N. Khan, Yushi Zhou   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Energy‐efficient switching method using input‐swapping for high‐resolution successive approximation register analog‐to‐digital converters

Electronics Letters
This paper presents an energy‐efficient digital‐to‐analog converter (DAC) switching method with low common‐mode variations for high‐resolution successive approximation register (SAR) analog‐to‐digital converters (ADCs), while enabling to implement ...
Serhat Kocak, Tayfun Akin
doaj   +1 more source

Metasurface on integrated photonic platform: from mode converters to machine learning

Nanophotonics, 2022
Integrated photonic circuits are created as a stable and small form factor analogue of fiber-based optical systems, from wavelength-division multiplication transceivers to more recent mode-division multiplexing components.
Wang Zi, Xiao Yahui, Liao Kun, Li Tiantian, Song Hao, Chen Haoshuo, Uddin S. M. Zia, Mao Dun, Wang Feifan, Zhou Zhiping, Yuan Bo, Jiang Wei, Fontaine Nicolas K., Agrawal Amit, Willner Alan E., Hu Xiaoyong, Gu Tingyi   +16 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Twice‐input variable‐resolution single‐side switching scheme without reset energy for SAR ADC

Electronics Letters
A twice‐input variable‐resolution single‐side switching scheme without reset energy is proposed for successive approximation register (SAR) analogue‐to‐digital converters (ADCs).
Bin Tang, Yunfeng Hu, QingMing Huang, Lexing Hu, Chaoyi Chen, Bin Li, Zhaohui Wu   +6 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Design automation of ΔΣ switched capacitor modulators using spice and MATLAB [PDF]

Serbian Journal of Electrical Engineering, 2014
Concerning the fact that the design of contemporary integrated circuits (IC) is practically impossible without using sophisticated Electronic Design Automation (EDA) software, this paper gives some interesting thoughts and considerations about ...
Mirković Dejan, Petković Predrag
doaj   +1 more source