Results 141 to 150 of about 11,917 (183)

Anandamide transport: A critical review

Life Sciences, 2005
Anandamide (AEA) uptake has been described over the last decade to occur by facilitated diffusion, but a protein has yet to be isolated. In some cell types, it has recently been suggested that AEA, an uncharged hydrophobic molecule, passively diffuses through the plasma membrane in a process that is not protein-mediated.
Sherrye T, Glaser, Martin, Kaczocha, Dale G, Deutsch   +2 more
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Anandamide vehicles: a comparative study

European Journal of Pharmacology, 2004
Among the studies that investigate the vasorelaxation induced by anandamide, one of the most frequent differences is the use of distinct solvents that could modify vascular function and explain the controversial results described. The aims of this study were: to evaluate the influence of different cannabinoid vehicles in vascular function of rat aorta,
Visitación, López-Miranda, Esperanza, Herradón, María Teresa, Dannert, Angela, Alsasua, María Isabel, Martín   +4 more
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Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues

Brain Research, 1998
Anandamide, an endogenous cannabinoid signaling molecule, in a concentration dependent manner, initiates the release of nitric oxide (NO) from leech and mussel ganglia. SR 141716A, a cannabinoid antagonist, blocks the anandamide stimulated release of NO from these tissues.
G B, Stefano, C M, Rialas, D G, Deutsch, M, Salzet   +3 more
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Enzymes for anandamide biosynthesis and metabolism

Journal of Lipid Mediators and Cell Signalling, 1996
Anandamide is an endogenous ligand for cannabinoid receptors. We tried to isolate and purify "anandamide amidohydrolase' which hydrolyzes anandamide to arachidonic acid and ethanolamine. The enzyme activity was found in the microsomal fraction of porcine brain homogenate.
N, Ueda, Y, Kurahashi, K, Yamamoto, S, Yamamoto, T, Tokunaga   +4 more
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Anandamide uptake explained?

Trends in Pharmacological Sciences, 2012
The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metabolism have been well characterised, the processes involved in uptake have been the subject of much controversy.
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Anandamide amidohydrolase (fatty acid amide hydrolase)

Prostaglandins & Other Lipid Mediators, 2000
Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
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Anandamide-loaded nanoparticles: Preparation and characterization

Journal of Microencapsulation, 2011
Preparation and characterization of anandamide (N-arachidonoyl-ethanolamine, AEA) loaded polycaprolactone nanoparticles (PCL NP) as a research tool to clarify the presence of an AEA transporter in cell membranes and to avoid AEA plastic adsorption and instability.High performance liquid chromatography and light scattering were used to determine ...
M R, Aberturas, D, Hernán Pérez de la Ossa, M E, Gil, A, Ligresti, L, Ligresti, L, De Petrocellis, A I, Torres, V, Di Marzo, J, Molpeceres   +8 more
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Solid-Phase Synthesis of Anandamide Analogues

Organic Letters, 2004
The endocannabinoids are amides and esters of arachidonic acid that can mimic the pharmacological properties of Delta(9)-tetrahydrocannabinol (Delta(9)-THC). Anandamide, the most prominent of the endocannabinoids, has been implicated in both metabolic/physiological roles of the central nervous system, making it an attractive medicinal target.
Longwu, Qi, Michael M, Meijler, Sang-Hyeup, Lee, Chengzao, Sun, Kim D, Janda   +4 more
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Toxicological assessment of anandamide

Archives of Clinical Toxicology
Anandamide (AEA), an endogenous cannabinoid, has been widely studied for its physiological roles and potential therapeutic applications. However, concerns remain regarding its safety profile, particularly at higher doses. Therefore, this study aimed to investigate the acute, subchronic and genetic toxicological effects of AEA.
Gloria Yi, George Gao, Wayne Yi, Long Jiang   +3 more
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Anandamide receptor signal transduction.

Vitamins and hormones, 2009
In the 15 years since its discovery anandamide has been implicated in many physiological processes. The signaling pathways mediating many of these processes are now coming to light, particularly in the CNS. The complexity of the cannabinoid system and the identification of many potential other receptors for anandamide have made conclusive evidence of ...
Catherine E, Goodfellow, Michelle, Glass
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