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Anandamide vehicles: a comparative study
European Journal of Pharmacology, 2004Among the studies that investigate the vasorelaxation induced by anandamide, one of the most frequent differences is the use of distinct solvents that could modify vascular function and explain the controversial results described. The aims of this study were: to evaluate the influence of different cannabinoid vehicles in vascular function of rat aorta,
Visitación, López-Miranda +4 more
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Anandamide transport: A critical review
Life Sciences, 2005Anandamide (AEA) uptake has been described over the last decade to occur by facilitated diffusion, but a protein has yet to be isolated. In some cell types, it has recently been suggested that AEA, an uncharged hydrophobic molecule, passively diffuses through the plasma membrane in a process that is not protein-mediated.
Sherrye T, Glaser +2 more
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Is GPR55 an anandamide receptor?
Vitamins and hormones, 2009Anandamide activates CB(1) cannabinoid receptors but also has effects, particularly in the vasculature, that cannot be explained by actions at either this or the other cloned cannabinoid receptor, the CB(2) receptor. These effects are probably mediated by a novel G protein-coupled receptor, but genome searching has not revealed a strong candidate ...
Andrew J, Brown, C, Robin Hiley
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Trends in Pharmacological Sciences, 2012
The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metabolism have been well characterised, the processes involved in uptake have been the subject of much controversy.
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The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metabolism have been well characterised, the processes involved in uptake have been the subject of much controversy.
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Toxicological assessment of anandamide
Archives of Clinical ToxicologyAnandamide (AEA), an endogenous cannabinoid, has been widely studied for its physiological roles and potential therapeutic applications. However, concerns remain regarding its safety profile, particularly at higher doses. Therefore, this study aimed to investigate the acute, subchronic and genetic toxicological effects of AEA.
Gloria Yi +3 more
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Enzymatic formation of anandamide.
Vitamins and hormones, 2009In animal tissues anandamide and other bioactive N-acylethanolamines are principally produced from glycerophospholipids through the transacylation-phosphodiesterase pathway consisting of two enzymatic reactions. The first reaction is the generation of N-acylphosphatidylethanolamine (NAPE) by transferring an acyl group esterified at sn-1 position of ...
Yasuo, Okamoto +2 more
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2008
Anandamide (arachidonoylethanolamide, AEA) acts as endogenous agonist of both cannabinoidand vanilloid receptors. During the last two decades, its metabolic pathways and biologicalactivity have been extensively investigated and relatively well-characterized.
Maccarrone M +7 more
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Anandamide (arachidonoylethanolamide, AEA) acts as endogenous agonist of both cannabinoidand vanilloid receptors. During the last two decades, its metabolic pathways and biologicalactivity have been extensively investigated and relatively well-characterized.
Maccarrone M +7 more
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