Results 111 to 120 of about 31,279 (264)
Altered Anandamide Degradation in Attention Deficit Hyperactivity Disorder
Pediatric Neurology Briefs, 2009 Anandamide (AEA) metabolism was investigated in 15 drug-free boys with ADHD (aged 6.5-13 years) and 15 age- and gender-matched healthy controls, in a study at Universita Tor Vergata, Rome, Italy.
J Gordon Millichap
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Recently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide].
Toshiya Endo +2 more
doaj +1 more source
Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart [PDF]
, 2009 Background Background K+ channels are the principal determinants of the resting membrane potential (RMP) in cardiac myocytes and thus, influence the magnitude and time course of the action potential (AP). Methods RT-PCR and in situ hybridization are used
Hengtao Zhang +3 more
core +2 more sources
Translational Psychiatry, 2014 Stress is a major risk factor for the development of mood and anxiety disorders; elucidation of novel approaches to mitigate the deleterious effects of stress could have broad clinical applications.
R. Bluett +5 more
semanticscholar +1 more source
Fatty acid metabolism—an emerging regulatory node in T‐cell immunometabolism
Clinical &Translational Immunology, Volume 15, Issue 4, 2026.Abstract While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T‐cell biology.
Brett Chapel Arenberg +2 more
wiley +1 more source
Moving bliss: a new anandamide transporter
Nature Neuroscience, 2011 A study now identifies a protein that mediates the cellular transport of the lipophilic endocannabinoid anandamide in aqueous environments.
Marsicano G, Chaouloff F.
openaire +2 more sources
The Endocannabinoid System as a Potential Therapeutic Target for Pain Modulation
Balkan Medical Journal, 2014 Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and
Ahmet Ulugöl
doaj +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
Science, 1997 Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into cells or by enzymatic ...
M. Beltramo +5 more
semanticscholar +1 more source
Evaluating FABP5 as a Therapeutic Target for Pain Management
European Journal of Pain, Volume 30, Issue 4, April 2026.ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren +4 more
wiley +1 more source