Results 111 to 120 of about 12,113 (164)
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Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
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Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
openaire +6 more sources
Anandamide and vanilloid TRPV1 receptors [PDF]
British Journal of Pharmacology, 2003 A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as
Ruth A Ross
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Oxidative metabolism of anandamide
Prostaglandins & Other Lipid Mediators, 2000In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.
S H, Burstein +3 more
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Biphasic Effects of Anandamide
Pharmacology Biochemistry and Behavior, 1998Effects of the endogenous cannabimimetic anandamide were assessed over a wide dose range in a series of physiological and behavioral assays. These included the tetrad of tests in mice commonly used to assess cannabinoid-induced effects (motor activity, ring catalepsy, hypothermia, and analgesia tests), as well as a model for agonistic behavior on ...
E, Sulcova, R, Mechoulam, E, Fride
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Cardiovascular pharmacology of anandamide
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular
Edward D, Högestätt, P M, Zygmunt
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Pharmacology & Therapeutics, 2004
N-Arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid CB1 and CB2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-THC), the active component of marijuana. As with any neurotransmitter, there must be tight control of anandamide receptor-mediated signaling
Matthew J, McFarland, Eric L, Barker
exaly +3 more sources
N-Arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid CB1 and CB2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-THC), the active component of marijuana. As with any neurotransmitter, there must be tight control of anandamide receptor-mediated signaling
Matthew J, McFarland, Eric L, Barker
exaly +3 more sources
The Biodisposition and Metabolism of Anandamide in Mice
The Journal of Pharmacology and Experimental Therapeutics, 1997The endogenous cannabinoid anandamide (AN) has been reported to produce pharmacological effects similar to those of delta9-tetrahydrocannabinol but with a shorter duration of action. Also, AN is known to be metabolized to arachidonic acid. The purpose of this study was to examine the time course of distribution and metabolism of AN. Male mice were each
K A, Willoughby +3 more
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Biosynthetic Pathways of the Endocannabinoid Anandamide
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yasuo, Okamoto +3 more
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Enzymes for anandamide biosynthesis and metabolism
Journal of Lipid Mediators and Cell Signalling, 1996Anandamide is an endogenous ligand for cannabinoid receptors. We tried to isolate and purify "anandamide amidohydrolase' which hydrolyzes anandamide to arachidonic acid and ethanolamine. The enzyme activity was found in the microsomal fraction of porcine brain homogenate.
N, Ueda +4 more
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Trends in Pharmacological Sciences, 2001
Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
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Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
openaire +2 more sources