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Anaphase B [PDF]

Biology, 2016
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Jonathan M. Scholey, Gul Civelekoglu-Scholey, Ingrid Brust-Mascher   +2 more
doaj   +4 more sources

Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase. [PDF]

Journal of Cell Biology, 1995
Gary J Gorbsky
exaly   +2 more sources

Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

PLoS Genetics, 2018
It is widely accepted in eukaryotes that the cleavage furrow only initiates after mitosis completion. In fission yeast, cytokinesis requires the synthesis of a septum tightly coupled to cleavage furrow ingression.
Juan Carlos G Cortés, Mariona Ramos, Mami Konomi, Iris Barragán, M Belén Moreno, María Alcaide-Gavilán, Sergio Moreno, Masako Osumi, Pilar Pérez, Juan Carlos Ribas   +9 more
doaj   +2 more sources

Single-motor and multi-motor motility properties of kinesin-6 family members

Biology Open, 2022
Kinesin motor proteins are responsible for orchestrating a variety of microtubule-based processes including intracellular transport, cell division, cytoskeletal organization, and cilium function.
Andrew Poulos, Breane G. Budaitis, Kristen J. Verhey   +2 more
doaj   +1 more source

Mechanical Mechanisms of Chromosome Segregation

Cells, 2021
Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing ...
Maya I. Anjur-Dietrich, Colm P. Kelleher, Daniel J. Needleman   +2 more
doaj   +1 more source

Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

eLife, 2022
During anaphase B, molecular motors slide interpolar microtubules to elongate the mitotic spindle, contributing to the separation of chromosomes. However, sliding of antiparallel microtubules reduces their overlap, which may lead to spindle breakage ...
Manuel Lera-Ramirez, François J Nédélec, Phong T Tran   +2 more
doaj   +1 more source

Blocking Protein Phosphatase 1 [PP1] Prevents Loss of Tether Elasticity in Anaphase Crane-Fly Spermatocytes

Frontiers in Molecular Biosciences, 2021
In normal anaphase cells, telomeres of each separating chromosome pair are connected to each other by tethers. Tethers are elastic at the start of anaphase: arm fragments cut from anaphase chromosomes in early anaphase move across the equator to the ...
Arthur Forer, Aisha Adil, Michael W. Berns, Michael W. Berns, Michael W. Berns, Michael W. Berns, Michael W. Berns, Michael W. Berns   +7 more
doaj   +1 more source

Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes

Life Science Alliance, 2023
Correlative live imaging with electron tomography provides evidence that physical filamentous connections extend between separating telomeres at all stages of anaphase.
Arthur Forer, Shotaro Otsuka
doaj   +1 more source

Depletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation

eLife, 2022
Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis, Hélène Bordelet, Agnès Thierry, Romain Koszul, Luis Aragon   +4 more
doaj   +1 more source

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source