Results 1 to 10 of about 66,678 (150)
Single-motor and multi-motor motility properties of kinesin-6 family members
Biology Open, 2022 Kinesin motor proteins are responsible for orchestrating a variety of microtubule-based processes including intracellular transport, cell division, cytoskeletal organization, and cilium function.
Andrew Poulos +2 more
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eLife, 2022 During anaphase B, molecular motors slide interpolar microtubules to elongate the mitotic spindle, contributing to the separation of chromosomes. However, sliding of antiparallel microtubules reduces their overlap, which may lead to spindle breakage ...
Manuel Lera-Ramirez +2 more
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Mechanical Mechanisms of Chromosome Segregation
Cells, 2021 Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing ...
Maya I. Anjur-Dietrich +2 more
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Frontiers in Molecular Biosciences, 2021 In normal anaphase cells, telomeres of each separating chromosome pair are connected to each other by tethers. Tethers are elastic at the start of anaphase: arm fragments cut from anaphase chromosomes in early anaphase move across the equator to the ...
Arthur Forer +7 more
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eLife, 2022 Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis +4 more
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PLoS Genetics, 2021 The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros +3 more
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Rif1 Regulates the Fate of DNA Entanglements during Mitosis
Cell Reports, 2016 Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger ...
Sophie Zaaijer +3 more
doaj +1 more source
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
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Polo-like kinase controls vertebrate spindle elongation and cytokinesis. [PDF]
PLoS ONE, 2007 During cell division, chromosome segregation must be coordinated with cell cleavage so that cytokinesis occurs after chromosomes have been safely distributed to each spindle pole.
Ian M Brennan +3 more
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Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
eLife, 2019 According to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However,
Olga Afonso +9 more
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