Results 1 to 10 of about 137,726 (160)
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
eLife, 2019 According to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However,
Olga Afonso +9 more
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Biology, 2016 Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Jonathan M. Scholey +2 more
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A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Cell Reports, 2016 To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su +5 more
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Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles
Biology, 2017 The separation of sister chromatids during anaphase is the culmination of mitosis and one of the most strikingly beautiful examples of cellular movement.
Charles L. Asbury
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Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
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Spatiotemporal regulation of the anaphase-promoting complex in mitosis
Nature Reviews Molecular Cell Biology, 2015 The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis.
Sushama Sivakumar +2 more
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Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]
PLoS ONE, 2016 Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona +6 more
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Nature Communications, 2018 Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase.
Zhe Wei +3 more
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TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
Journal of Cell Biology, 2014 TopBP1/Dpb11 prevents accumulation of anaphase chromatin bridges by stimulating the Mec1/ATR kinase and suppressing homologous recombination.
Susanne M Germann +2 more
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Journal of Cell Biology, 1995 During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome acquires a bipolar attachment to the spindle--an event that may require 3 h (Rieder, C. L., A. Schultz, R. W.
Conly L Rieder +2 more
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