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Anaphase B [PDF]

open access: yesBiology, 2016
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Jonathan M. Scholey   +2 more
doaj   +6 more sources

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

open access: yeseLife, 2019
According to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However,
Olga Afonso   +9 more
doaj   +2 more sources

Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles

open access: yesBiology, 2017
The separation of sister chromatids during anaphase is the culmination of mitosis and one of the most strikingly beautiful examples of cellular movement.
Charles L. Asbury
doaj   +2 more sources

Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. [PDF]

open access: bronzeThe Journal of cell biology, 1994
A novel anaphase block phenotype was found in fission yeast temperature-sensitive cut9 mutants. Cells enter mitosis with chromosome condensation and short spindle formation, then block anaphase, but continue to progress into postanaphase events such as degradation of the spindle, reformation of the postanaphase cytoplasmic microtubule arrays, septation,
Itaru Samejima, Mitsuhiro Yanagida
openalex   +4 more sources

Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B

open access: yesMolecular Biology of the Cell, 2019
Spindle microtubules, whose dynamics vary over time and at different locations, cooperatively drive chromosome segregation. Measurements of microtubule dynamics and spindle ultrastructure can provide insight into the behaviors of microtubules, helping ...
Che-Hang Yu   +8 more
semanticscholar   +4 more sources

The anaphase-promoting complex: proteolysis in mitosis and beyond. [PDF]

open access: yesMolecular Cell, 2002
Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and ...
J. Peters
semanticscholar   +4 more sources

Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

open access: yesNature Communications, 2018
Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase.
Zhe Wei   +3 more
doaj   +2 more sources

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]

open access: yesPLoS ONE, 2016
Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona   +6 more
doaj   +2 more sources

A Wee1 checkpoint inhibits anaphase onset [PDF]

open access: yesJournal of Cell Biology, 2013
The budding yeast Wee1 kinase Swe1 restrains the metaphase-to-anaphase transition by preventing the Cdk1-dependent phosphorylation and activation of APCCdc20.
Noel Lianga   +7 more
semanticscholar   +4 more sources

Blocking microtubule deacetylation inhibits anaphase chromosome movements in crane-fly spermatocytes. [PDF]

open access: yesPLoS ONE
Chromosome movement speeds during anaphase are regulated by depolymerization of microtubules. Several models describe chromosome movement during cell division but none of them consider post-translational modifications of tubulin, even though such ...
Maral Janan   +2 more
doaj   +2 more sources

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