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The role of complement in long COVID pathogenesis. [PDF]
JCI InsightBayarri-Olmos R, Bain W, Iwasaki A.
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Vaginal Clinical Isolates of <i>Candida albicans</i> Differentially Modulate Complosome Activation in Vaginal Epithelial Cells. [PDF]
J Fungi (Basel)Kenno S +8 more
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Anaphylatoxins in organ transplantation
Seminars in Immunology, 2013C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses.
Li, Ke, Zhou, Wuding
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Advances in Immunology, 1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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Immunologic Research, 2007
Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation
Pieter-Jan, Haas, Jos, van Strijp
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Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation
Pieter-Jan, Haas, Jos, van Strijp
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Structure and Function of the Anaphylatoxins
Springer Seminars in Immunopathology, 1984Chemical and physical characterization of the anaphylatoxin molecules have provided a reasonably clear description of the architecture of these bioactive proteins. The primary structures of C3a, C4a, and C5a from man and from a number of animal species have been elucidated, and it is apparent that the three anaphylatoxins are genetically related.
T. Hugli
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Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment.
Seminars in Cell and Developmental Biology, 2017Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These two complement activation products can maintain chronic inflammation,
D. Ajona, S. Ortiz-Espinosa, R. Pio
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American Journal of Respiratory Cell and Molecular Biology, 2019
&NA; In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE).
L. Luo +6 more
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&NA; In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE).
L. Luo +6 more
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Anaphylatoxins in dilated cardiomyopathy
Journal of Internal Medicine, 1993Abstract. Objects. The aim of the study was to investigate the possible relationship between activation of complement system and thromboembolic complications in dilated cardiomyopathy (DCMP).Methods. The plasma C3a and C5a concentrations were determined by radioimmunoassay measurement (Amersham International, UK) in 23 patients with DCMP, 9 with ...
M, Samsonov +5 more
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