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Effects of the anaphylatoxins on circulation
Immunopharmacology, 1987Anaphylatoxins (e.g. activation fragments C3a, C4a and C5a) are bioactive cleavage products released from plasma components C3, C4 and C5, respectively, during complement activation. The biologic role of anaphylatoxins is generally characterized as pro-inflammatory, since these factors recruit numerous tissue mediators of the host defense system.
François Marceau
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Anaphylatoxins in organ transplantation
Seminars in Immunology, 2013C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses.
Li, Ke, Zhou, Wuding
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Anaphylatoxins in dilated cardiomyopathy
Journal of Internal Medicine, 1993Abstract. Objects. The aim of the study was to investigate the possible relationship between activation of complement system and thromboembolic complications in dilated cardiomyopathy (DCMP).Methods. The plasma C3a and C5a concentrations were determined by radioimmunoassay measurement (Amersham International, UK) in 23 patients with DCMP, 9 with ...
M, Samsonov +5 more
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1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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Journal of the American Medical Association, 1924
The liver is the first organ for which a function of internal secretion was predicted by Claude Bernard. Our knowledge of hepatic physiology is so scanty, however, that modern textbooks on endocrinology rarely mention the liver as a possible site of hormone formation.
W. H. MANWARING +3 more
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The liver is the first organ for which a function of internal secretion was predicted by Claude Bernard. Our knowledge of hepatic physiology is so scanty, however, that modern textbooks on endocrinology rarely mention the liver as a possible site of hormone formation.
W. H. MANWARING +3 more
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Anaphylatoxin Formation in Sepsis
Archives of Surgery, 1988Complement activation and anaphylatoxin formation were studied in 27 septic patients. The patients were treated with antibiotics and high-dose corticosteroids. Blood samples were drawn on admission and every week thereafter. Plasma levels of complement components C1INH, C3, C4, and C5 were low before the start of treatment but were above normal one ...
A, Bengtson, M, Heideman
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Histamine Release by Anaphylatoxin
Nature, 1951EARLY studies of the mechanism of anaphylaxis led to two apparently contradictory views : the so-called ‘humoral theory’, according to which the blood is the site of production of a toxin, the anaphylatoxin1–4; and the ‘cellular theory’, which localizes the anaphylactic reaction in the cells, and assumes that this reaction causes the release of ...
M, ROCHA E SILVA, O, BIER, M, ARONSON
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Journal of the American Medical Association, 1924
In previous papers it was shown that characteristic anaphylactic contractions of the urinary bladder 1 and of the gastro-intestinal tract 2 do not take place in dehepatized anaphylactic dogs. The conclusion was drawn that the typical anaphylactic contractions of these organs are due to chemical products (hepatic anaphylatoxins) explosively formed or ...
W. H. MANWARING +3 more
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In previous papers it was shown that characteristic anaphylactic contractions of the urinary bladder 1 and of the gastro-intestinal tract 2 do not take place in dehepatized anaphylactic dogs. The conclusion was drawn that the typical anaphylactic contractions of these organs are due to chemical products (hepatic anaphylatoxins) explosively formed or ...
W. H. MANWARING +3 more
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Anaphylatoxin and Anaphylaxis: XI. Ultra-Filtration and Fractionation of Anaphylatoxin
Journal of Infectious Diseases, 1919Despite the large amount of study on the nature of anaphylatoxin and of the mechanism of its formation, little if any attempt has been made to isolate the toxic principle on one or the other of the protein fractions of the serum. Various serum principles having physiologic activity, but of unknown chemical nature, have been isolated on the protein ...
P. H. De Kruif, A. H. Eggerth
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The anaphylatoxin-forming system
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1967Introduct ion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . t 60 I. Format ion of anaphylatoxin. Evidence for an enzymic mechanism . . . . . t 62 II . The components of the anaphyla toxin system . . . . . . . . . . . . . . . 165 A. The anaphylatoxin-forming enzymes . . . . . . . . . . . . . . . . . 165 1. The cobra enzyme . . . . . . . .
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