Results 181 to 190 of about 7,925 (224)
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Anaphylatoxin generation in acute pancreatitis
Journal of Surgical Research, 1989Fifty-one patients with elevated serum amylase and clinical signs of acute pancreatitis were studied prospectively. The concentrations of anaphylatoxins (C3a and C5a) were measured with a radioimmunoassay and the activity of their inactivator was determined.
L, Roxvall, A, Bengtson, M, Heideman
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Anaphylatoxins in fresh‐frozen plasma
Transfusion, 1997BACKGROUND: Fresh‐frozen plasma (FFP) is widely used in patients with coagulation disorders and simultaneous complement activation. Complement activation in FFP itself is poorly investigated. STUDY DESIGN AND METHODS: The concentration of anaphylatoxins C3a and C5a, the complement precursors C1q and factor B, and complement function were measured in 40
J, Sonntag +3 more
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Designing synthetic superagonists of C3a anaphylatoxin
Biochemistry, 1991An extensive structure-activity study of synthetic analogues of the C3a anaphylatoxin was conducted. Our goal was to map C3a-C3a receptor interactions by designing synthetic analogue molecules having maximal biologic potency. Nonspecific binding of the polycationic C3a to polyanionic molecules on cellular surfaces often obscures specific binding to the
J A, Ember, N L, Johansen, T E, Hugli
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1997
Abstract As well as opsonization and cytolysis by C3 degradation products and the membrane attack complex, the activation of the complement system results in the generation of the proinflammatory polypeptides C3a, C4a, C5a, and C5adesArg, which are collectively described as anaphylatoxins or anaphylatoxic peptides (AT peptides).
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Abstract As well as opsonization and cytolysis by C3 degradation products and the membrane attack complex, the activation of the complement system results in the generation of the proinflammatory polypeptides C3a, C4a, C5a, and C5adesArg, which are collectively described as anaphylatoxins or anaphylatoxic peptides (AT peptides).
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Biochemistry and Biology of Anaphylatoxins
Complement, 1986The molecular architecture of anaphylatoxins has been explored on several levels. Primary, secondary and tertiary structural parameters that dictate function of the C3a, C4a and C5a molecules are being elucidated with the aid of comparative sequence analyses, physical measurements and organic syntheses.
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Formation of anaphylatoxin in human serum
Experientia, 1969Es ist moglich, auch in menschlichem Serum eine Anaphylatoxinbildung (AT) durch Kontaktaktivierung oder Kobragift zu induzieren. Wegen der geringen Mengen, die entstehen, muss das wirksame Prinzip vor dem biologischen Nachweis angereichert werden. Menschliches AT verhalt sich in allen untersuchten Eigenschaften wie AT aus anderen Plasmaarten.
W, Vogt +3 more
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Anaphylatoxin Formation in Extracorporeal Circuits
Complement, 1986Anaphylatoxin radioimmunoassay techniques have been employed to define both the temporal profile and the amount of complement activation taking place in two different types of extracorporeal circuits. Prospective studies of patients undergoing both maintenance hemodialysis and cardiopulmonary bypass provided essentially similar findings. In both cases,
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Anaphylatoxins: Possible Roles in Disease
Complement, 1986Anaphylatoxins, in particular C3a and C5a, have various biological activities which suggest a role as mediators of inflammatory reactions: they cause contraction of smooth muscle, histamine release, increase in capillary permeability, adhesion of leukocytes to vascular endothelium, leukocyte chemotaxis, and aggregation of platelets and leukocytes. Most
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Structure and Function of the Anaphylatoxins
Springer Seminars in Immunopathology, 1984Chemical and physical characterization of the anaphylatoxin molecules have provided a reasonably clear description of the architecture of these bioactive proteins. The primary structures of C3a, C4a, and C5a from man and from a number of animal species have been elucidated, and it is apparent that the three anaphylatoxins are genetically related.
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