Results 71 to 80 of about 10,975 (239)

Pathophysiological changes in patients during hemodialysis and blood reinfusion predict potential development of hemodialysis reactions

Renal Failure
Hemodialysis reactions (HDRs) are a type of hypersensitivity reactions (HSRs), such as complement activation-related pseudoallergy (CARPA) observed during nanoparticle infusions.
Ákos Géza Pethő, Csaba Révész, Tamás Mészáros, Orsolya Sáfár, László Rosivall, József Domán, Gábor Szénási, Tünde Gigacz, László Dézsi   +8 more
doaj   +1 more source

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, Volume 22, Issue 11, 20 February 2026.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source

Clinical analysis of selected complement-derived molecules in human adipose tissue

Journal of Translational Medicine, 2013
Background It has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders.
Błogowski Wojciech, Budkowska Marta, Sałata Daria, Serwin Karol, Dołęgowska Barbara, Łokaj Marek, Prowans Piotr, Starzyńska Teresa   +7 more
doaj   +1 more source

Aluminum hydroxide adjuvant differentially activates the three complement pathways with major involvement of the alternative pathway. [PDF]

PLoS ONE, 2013
Al(OH)3 is the most common adjuvant in human vaccines, but its mode of action remains poorly understood. Complement involvement in the adjuvant properties of Al(OH)3 has been suggested in several reports together with a depot effect. It is here confirmed
Esin Güven, Karen Duus, Inga Laursen, Peter Højrup, Gunnar Houen   +4 more
doaj   +1 more source

Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease [PDF]

, 2015
Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and
Crean, Stjohn, Harding, Alice, Kesavalu, Lakshmyya, Poole, Sophie, Singhrao, Simarjit Kaur   +4 more
core   +3 more sources

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

Dextran sulfate activates the contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C., Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kohl, Jacek, Siebeck, Matthias, Spannagl, Michael, Spies, Bernd   +7 more
core   +4 more sources

Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]

, 1982
Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T ...
Goetzl, EJ, Payan, DG, Trentham, DE
core  

First successful protocol for desensitization to eptinezumab

Headache: The Journal of Head and Face Pain, Volume 66, Issue 2, Page 556-559, February 2026.
Abstract Background Eptinezumab is an anti‐calcitonin gene‐related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E–mediated, the team of Nice University Hospital (Nice, France) performed
Benoit Gerard, Hubert Praudel, Michel Lanteri‐Minet, Elise Van Obberghen, Fanny Rocher‐Moreau, Johanna Rousset, Ulysse Jacquier, Sylvie Leroy, Margot Delin   +8 more
wiley   +1 more source