Results 11 to 20 of about 1,888,402 (158)

Virological characterization of a new isolated strain of Andes virus involved in the recent person-to-person transmission outbreak reported in Argentina. [PDF]

PLoS Neglected Tropical Diseases
On November 2, 2018, a person-to-person transmission outbreak of Andes virus (Orthohantavirus andesense) began in the small town of Epuyén, Argentina. The strain demonstrated a high capacity for sustained transmission among the human population requiring
Rocio Coelho, Sebastian Kehl, Natalia Periolo, Emiliano Biondo, Daniel Alonso, Celeste Perez, Darío Fernández Do Porto, Gustavo Palacios, Alexis Edelstein, Carla Bellomo, Valeria Paula Martinez   +10 more
doaj   +4 more sources

New Andes virus isolate haplotype obtained during prospective close contacts follow-up of an Hantavirus cardiopulmonary syndrome fatal case, Chile [PDF]

Current Research in Microbial Sciences
Andes virus (ANDV) is a zoonotic orthohantavirus that causes hantavirus cardiopulmonary syndrome. Transmission occurs mainly through contact with infected rodent excreta and, less frequently, between humans. Viral isolation from human samples is rare; in
Aldo Barrera, Hade Ramos, Eugenia Fuentes-Luppichini, Constanza Martínez-Valdebenito, Javiera Pradenas, Catalina Rogers, Carlos Palma, Claudia Campillo, Maritza Navarrete, Nicole Le Corre, Jenniffer Angulo, Marcela Ferrés   +11 more
doaj   +3 more sources

“Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina

New England Journal of Medicine, 2020
BACKGROUND From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted in 34 confirmed infections and 11 deaths.
Nicholas Di Paola, Unai Pérez-Sautu, Natalia Periolo   +2 more
exaly   +5 more sources

Bivalent VSV Vectors Mediate Rapid and Potent Protection from Andes Virus Challenge in Hamsters [PDF]

Viruses
Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human–human transmission. Therefore, emergency vaccination would be a valuable public
Joshua Marceau, David Safronetz, Cynthia Martellaro, Andrea Marzi, Kyle Rosenke, Heinz Feldmann   +5 more
doaj   +3 more sources

Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine. [PDF]

Nat Commun
The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA).
Kuzmin IV, Soto Acosta R, Pruitt L, Wasdin PT, Kedarinath K, Hernandez KR, Gonzales KA, Hill K, Weidner NG, Mire C, Engdahl TB, Moon WJ, Popov V, Crowe JE, Georgiev IS, Garcia-Blanco MA, Abbott RK, Bukreyev A.   +17 more
europepmc   +5 more sources

Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study. [PDF]

J Infect Dis, 2023
BACKGROUND Andes virus (ANDV), a rodent-borne hantavirus, causes hantavirus pulmonary syndrome (HPS). The safety and immunogenicity of a novel ANDV DNA vaccine was evaluated.
Paulsen GC, Frenck R, Tomashek KM, Alarcon RM, Hensel E, Lowe A, Brocato RL, Kwilas SA, Josleyn MD, Hooper JW.   +9 more
europepmc   +2 more sources

Andes Virus Genome Mutations That Are Likely Associated with Animal Model Attenuation and Human Person-to-Person Transmission. [PDF]

mSphere, 2023
Several orthohantaviruses cause the zoonotic disease hantavirus pulmonary syndrome (HPS) in the Americas. Among them, HPS caused by Andes virus (ANDV) is of great public health concern because it is associated with the highest case fatality rate (up to ...
Bellomo CM, Alonso DO, Pérez-Sautu U, Prieto K, Kehl S, Coelho RM, Periolo N, Di Paola N, Ferressini-Gerpe N, Kuhn JH, Sanchez-Lockhart M, Palacios G, Martínez VP.   +12 more
europepmc   +2 more sources

Binding of the Andes Virus Nucleocapsid Protein to RhoGDI Induces the Release and Activation of the Permeability Factor RhoA. [PDF]

J Virol, 2021
HPS-causing hantaviruses infect pulmonary endothelial cells (ECs), causing vascular leakage, pulmonary edema, and a 35% fatal acute respiratory distress syndrome (ARDS).
Gorbunova EE, Mackow ER.
europepmc   +2 more sources

Differential pathogenesis between Andes virus strains CHI-7913 and Chile-9717869in Syrian Hamsters. [PDF]

J Virol, 2021
Andes orthohantavirus (ANDV) is a New World hantavirus that is a major cause of hantavirus cardiopulmonary syndrome (HCPS; also referred to as hantavirus pulmonary syndrome) in South America, particularly in Chile and Argentina.
Warner BM, Sloan A, Deschambault Y, Dowhanik S, Tierney K, Audet J, Liu G, Stein DR, Lung O, Buchanan C, Sroga P, Griffin BD, Siragam V, Frost KL, Booth S, Banadyga L, Saturday G, Scott D, Kobasa D, Safronetz D.   +19 more
europepmc   +2 more sources

High genomic stability of Andes virus following successive passage <i>in vivo</i> in Syrian hamsters. [PDF]

J Virol
Andes virus (ANDV) is a South American hantavirus that causes hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory infection with a case fatality rate as high as 40%.
Warner BM, Prévost J, Tailor N, Deschambault Y, Sloan A, Allarie J, Klassen L, Frost K, Booth S, Audet J, Soule G, Safronetz D.   +11 more
europepmc   +2 more sources