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Person-to-Person Transmission of Andes Virus

Emerging Infectious Diseases, 2005
Despite the fact that rodents are considered to be the infectious source of hantavirus for humans, another route of transmission was demonstrated. Andes virus (ANDV) has been responsible for most of the cases recorded in Argentina.
Valeria P. Martinez, Carla Bellomo, Jorge San Juan, Diego Pinna, Raul Forlenza, Malco Elder, Paula J. Padula   +6 more
doaj   +3 more sources

Viral shedding and viraemia of Andes virus during acute hantavirus infection: a prospective study. [PDF]

Lancet Infect Dis
BACKGROUND Andes virus (ANDV) is a zoonotic Orthohantavirus leading to hantavirus cardiopulmonary syndrome. Although most transmissions occur through environmental exposure to rodent faeces and urine, rare person-to-person transmission has been ...
Ferrés M, Martínez-Valdebenito C, Henriquez C, Marco C, Angulo J, Barrera A, Palma C, Barriga Pinto G, Cuiza A, Ferreira L, Rioseco ML, Calvo M, Fritz R, Bravo S, Bruhn A, Graf J, Llancaqueo A, Rivera G, Cerda C, Tischler N, Valdivieso F, Vial P, Mertz G, Vial C, Le Corre N.   +24 more
europepmc   +2 more sources

Andes Virus and First Case Report of Bermejo Virus Causing Fatal Pulmonary Syndrome [PDF]

Emerging Infectious Diseases, 2002
Two suspected hantavirus pulmonary syndrome (HPS) cases from Bolivia were confirmed by enzyme-linked immunosorbent assay. (ELISA)-ANDES was performed using N-Andes recombinant antigen serology in May and July 2000.
Paula Padula, Marcelo González Della Valle, María Garcia Alai, Pedro Cortada, Mario Villagra, Alberto Gianella   +5 more
doaj   +3 more sources

First Human Isolate of Hantavirus (Andes virus) in the Americas

Emerging Infectious Diseases, 2002
We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS).
Hector Galeno, Judith Mora, Eliecer Villagra, Jorge Fernandez, Jury Hernandez, Gregory J. Mertz, Eugenio Ramirez   +6 more
doaj   +3 more sources

In Vitro and In Vivo Activity of Ribavirin against Andes Virus Infection [PDF]

PLoS ONE, 2011
Pathogenic hantaviruses are a closely related group of rodent-borne viruses which are responsible for two distinct diseases in humans, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome (HPS, otherwise known as hantavirus cardiopulmonary syndrome, HCPS). The antiviral effect of ribavirin against Old World hantaviruses, most notably
David Safronetz, Elaine Haddock, Friederike Feldmann   +2 more
exaly   +6 more sources

A Single-Nucleotide Polymorphism of α_Vβ₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. [PDF]

Viruses, 2019
The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between
Martínez-Valdebenito C, Angulo J, Le Corre N, Marco C, Vial C, Miquel JF, Cerda J, Mertz G, Vial P, Lopez-Lastra M, Ferrés M.   +10 more
europepmc   +2 more sources

Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells. [PDF]

PLoS One, 2016
Andes virus (ANDV) is the major cause of hantavirus pulmonary syndrome (HPS) in South America. Despite a high fatality rate (up to 40%), no vaccines or antiviral therapies are approved to treat ANDV infection. To understand the role of endocytic pathways
Chiang CF, Flint M, Lin JS, Spiropoulou CF.   +3 more
europepmc   +2 more sources

Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386. [PDF]

J Virol, 2019
ANDV contains virulence determinants that uniquely permit it to spread person to person and cause highly lethal HPS in immunocompetent hamsters. We discovered that ANDV S386 and an ANDV-specific hypervariable domain permit ANDV N to inhibit IFN induction
Simons MJ, Gorbunova EE, Mackow ER.
europepmc   +2 more sources

Notes from the Field: Contact Tracing Investigation after First Case of Andes Virus in the United States - Delaware, February 2018. [PDF]

MMWR Morb Mortal Wkly Rep, 2018
Contact Tracing Investigation after First Case of Andes Virus in the United States — Delaware, February 2018 Aaron Kofman, MD1,2; Paula Eggers3; Anne Kjemtrup, DVM, PhD4; Rebecca Hall, MPH5; Shelley M. Brown2; Maria Morales-Betoulle, PhD2; James Graziano,
Kofman A, Eggers P, Kjemtrup A, Hall R, Brown SM, Morales-Betoulle M, Graziano J, Zufan SE, Whitmer SLM, Cannon DL, Chiang CF, Choi MJ, Rollin PE, Cetron MS, Yaglom HD, Duwell M, Kuhar DT, Kretschmer M, Knust B, Klena JD, Alvarado-Ramy F, Shoemaker T, Towner JS, Nichol ST.   +23 more
europepmc   +2 more sources

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. [PDF]

mBio, 2016
Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (HPS).
Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER.   +3 more
europepmc   +2 more sources