Results 51 to 60 of about 310,378 (283)
Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Frontiers in Oncology, 2019 Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic ...
Q. Feng, B. He
semanticscholar +1 more source
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
Frontiers in Immunology, 2018 Sex differences in the incidence and severity of respiratory virus infection are widely documented in humans and murine models and correlate with sex biases in numbers and/or functional responses of innate immune cells in homeostasis and lung infection ...
Sapana Kadel +3 more
doaj +1 more source
PCONet: A Convolutional Neural Network Architecture to Detect Polycystic Ovary Syndrome (PCOS) from Ovarian Ultrasound Images [PDF]
arXiv, 2022 Polycystic Ovary Syndrome (PCOS) is an endrocrinological dysfunction prevalent among women of reproductive age. PCOS is a combination of syndromes caused by an excess of androgens - a group of sex hormones - in women. Syndromes including acne, alopecia, hirsutism, hyperandrogenaemia, oligo-ovulation, etc. are caused by PCOS. It is also a major cause of
arxiv
Journal of Clinical Endocrinology and Metabolism, 2006 OBJECTIVE The Androgen Excess Society (AES) charged a task force to review all available data and recommend an evidence-based definition for polycystic ovary syndrome (PCOS), whether already in use or not, to guide clinical diagnosis and future research.
R. Azziz +10 more
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Frontiers in Endocrinology, 2018 Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes.
Julia S. Barthold, Richard Ivell
doaj +1 more source
Frontiers in Neuroscience, 2020 Sleep debt is becoming a better acknowledged cause of physiological stress and neurobehavioral deficits with major public-health concerns. We investigated whether exposure to blue light during daytime could be an efficient countermeasure to limit sleep ...
Brice Faraut +19 more
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Towards Personalized Prostate Cancer Therapy Using Delta-Reachability Analysis [PDF]
, 2014 Recent clinical studies suggest that the efficacy of hormone therapy for prostate cancer depends on the characteristics of individual patients. In this paper, we develop a computational framework for identifying patient-specific androgen ablation therapy schedules for postponing the potential cancer relapse.
arxiv +1 more source
Androgen Signaling in Prostate Cancer.
Cold Spring Harbor Perspectives in Medicine, 2017 The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has remained a mainstay of therapy for advanced disease.
Charles Dai, H. Heemers, N. Sharifi
semanticscholar +1 more source
Androgen Receptor and Mechanism of Androgen Action
Annals of Medicine, 1993 Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner.
Pekka Kallio +3 more
openaire +3 more sources
JCI Insight, 2019 Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss.
M. O’Reilly +18 more
semanticscholar +1 more source