Results 51 to 60 of about 346,728 (197)

Androgen receptor: structure, role in prostate cancer and drug discovery

Acta Pharmacologica Sinica, 2014
Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade
MH Eileen Tan, LI Jun, XU HEric, K. Melcher, Eu-leong Yong   +4 more
semanticscholar   +1 more source

Evaluating the Term ‘Disorders of Sex Development’: A Multidisciplinary Debate

Social Medicine, 2018
In 2014, almost 10 years after the 2005 International Consensus Conference on Intersex in Chicago, one of the conference co-organisers, under the auspices of a number of international paediatric endocrinology societies, launched the Global DSD Update to ...
Natalie Delimata, Margaret Simmonds, Michelle O’Brien, Georgiann Davis, Richard Auchus, Karen Lin-Su   +5 more
doaj  

Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells

BioTechniques, 2021
Due to the public health concerns of endocrine-disrupting chemicals, there is an increasing demand to develop improved high-throughput detection assays for enhanced exposure control and risk assessment. A substrate-free, autobioluminescent HEK293ARE/Gal4-
Tingting Xu, Madison Gilliam, Gary Sayler, Steven Ripp, Dan Close   +4 more
doaj   +1 more source

The unique interplay of mitochondrial oxidative phosphorylation (OXPHOS) and immunity and its potential implication for the sex‐ and age‐related morbidity of severe COVID‐19 patients

MedComm, 2023
Aged male patients are more vulnerable to severe or critical symptoms of COVID‐19, but the underlying mechanism remains elusive. In this study, we analyzed previously published scRNA‐seq data from a large cohort of COVID‐19 patients, castrated and ...
Yinchuan Li, Lei Li, Guanghao Wu, Gangcai Xie, Lirong Yi, Jie Zhu, ShiYu Liang, Ya‐ru Huang, Juan Chen, Shaoyang Ji, Fei Sun, Rui‐tian Liu   +11 more
doaj   +1 more source

One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia

Frontiers in Endocrinology, 2022
In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation.
Ciro M. Amato, Humphrey H-C. Yao, Fei Zhao   +2 more
doaj   +1 more source

Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation

Journal of Immunology, 2018
Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar macrophages (AM).
Mireya Becerra-Díaz, Ashley B. Strickland, Aleksander Keselman, N. Heller   +3 more
semanticscholar   +1 more source

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua, CAI Shiliang, LIU Donghong, CHEN Hongsen, CAO Guangwen   +4 more
doaj   +1 more source

AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome

Journal of Clinical Endocrinology and Metabolism, 2017
Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk.
M. O’Reilly, Punith Kempegowda, Mark Walsh, A. Taylor, Konstantinos N. Manolopoulos, W. J. Allwood, R. Semple, D. Hebenstreit, W. Dunn, J. Tomlinson, W. Arlt   +10 more
semanticscholar   +1 more source

Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling [PDF]

, 2021
Anbarasi Kothandapani, Colin R. Jefcoate, Joan S. Jorgensen   +2 more
openalex   +1 more source

Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway

Cancer Medicine, 2023
Background Since the human papillomavirus vaccines do not eliminate preexisting infections, nonsurgical alternative approaches to cervical intraepithelial neoplasia (CIN) have been required.
Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai, Junpei Iwadare, Ayumi Matsuoka, Kayo Kayahashi, Kousho Wakae, Masamichi Muramatsu, Satoru Kyo, Yasuhiko Yamamoto, Yasunari Mizumoto, Takiko Daikoku, Hiroshi Fujiwara   +19 more
doaj   +1 more source