Results 61 to 70 of about 346,728 (197)

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.

ACS Chemical Biology, 2016
Castration-resistant prostate cancer is the lethal condition suffered by prostate cancer patients that become refractory to androgen deprivation therapy.
E. de Mol, R. B. Fenwick, Christopher T. W. Phang, Víctor Buzón, E. Szulc, Alex de la Fuente, A. Escobedo, Jesús García, C. Bertoncini, E. Estébanez-Perpiñá, I. McEwan, Antoni Riera, X. Salvatella   +12 more
semanticscholar   +1 more source

Complete androgen insensitivity syndrome or testicular feminization: review of literature based on a case report

The Pan African Medical Journal, 2016
Testicular feminization, or the androgen insensitivity syndrome, is a rare disease. Because of various abnormalities of the X chromosome, a male, genetically XY, has some physical characteristics of a woman or a full female phenotype. Indeed the androgen
Regragui Souhail, Slaoui Amine, Abounouh Nadia, Karmouni Tarik, El Khader Khalid, Koutani Abdellatif, Ibn Attya Ahmed   +6 more
doaj   +1 more source

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

Oncogene, 2013
Prostate cancer is the second-leading cause of cancer-related mortality in men in Western societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer cells, and androgen-deprivation therapy (ADT) remains the principal ...
T. Karantanos, P. Corn, T. Thompson
semanticscholar   +1 more source

Analysis of Ratio of Length of 2nd Digit to 4th Digit (2D:4D) among Transgender Women (MtF) and Cisgender People in South Indian Population: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Transgender refers to an individual whose gender identity differs from the sex that was assigned at birth. Transgender women (MtF) were assigned male at birth but later recognised themselves as female. The length of the index finger (2D) in
Karthikeyan Annamalai, Deepti Shastri, Sathiya Subramaniam   +2 more
doaj   +1 more source

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

Nature Communications, 2016
Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but how
Menglei Zhu, Pearl Bakhru, Bridget Conley, J. Nelson, M. Free, Aaron J. Martin, J. Starmer, E. Wilson, M. Su   +8 more
semanticscholar   +1 more source

A concise review of testosterone and bone health

Clinical Interventions in Aging, 2016
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lampur, Malaysia Abstract: Osteoporosis is a condition causing significant morbidity and mortality in the elderly
Mohamad NV, Soelaiman IN, Chin KY
doaj  

The Smoothened agonist SAG Modulates the Male and Female Peripheral Immune Systems Differently in an Immune Model of Central Nervous System Demyelination

Cells
Both Hedgehog and androgen signaling pathways are known to promote myelin regeneration in the central nervous system. Remarkably, the combined administration of agonists of each pathway revealed their functional cooperation towards higher regeneration in
Abdelmoumen Kassoussi, Amina Zahaf, Tom Hutteau-Hamel, Claudia Mattern, Michael Schumacher, Pierre Bobé, Elisabeth Traiffort   +6 more
doaj   +1 more source

Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus

Acta Dermato-Venereologica, 2018
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder.
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan   +6 more
doaj   +1 more source

Androgen Receptor Signaling in Bladder Cancer

Cancers, 2017
Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor ...
Peng Li, Jinbo Chen, H. Miyamoto
semanticscholar   +1 more source

Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish

Frontiers in Neuroscience, 2015
Steroid hormones are critical regulators of reproductive life history, and the steroid sensitive traits (morphology, behavior, physiology) associated with particular life history stages can have substantial fitness consequences for an organism. Hormones,
Devaleena S Pradhan, Devaleena S Pradhan, Tessa K Solomon-Lane, Matthew Scott Grober, Matthew Scott Grober   +4 more
doaj   +1 more source