Results 61 to 70 of about 310,378 (283)
Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications
Frontiers in Oncology, 2023 Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival of non-small cell lung cancer (NSCLC) patients. However, differential responses have been observed by sex, where men appear to respond better than women.
Vianey Rodriguez-Lara +7 more
doaj +1 more source
The Androgen Receptor in Breast Cancer
Frontiers in Endocrinology, 2018 Breast cancer (BC) is a hormone-related tumor. Despite the progress in BC therapy, this disease still remains the most common cancer amongst women around the world. This is likely due to the amazing BC heterogeneity. Accumulating evidence suggests a role
P. Giovannelli +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
COVID‐19, androgens, and androgenic alopecia [PDF]
Dermatological Reviews, 2020 AbstractThe severity of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in males may be due to the higher androgen expression. It is also known that androgen sensitivity is correlated with androgenic alopecia. The “Gabrin sign” identifies those with severe androgen alopecia (Hamilton Norwood scale = 3–7) who are at a higher risk for ...
Wambier, Carlos Gustavo +3 more
openaire +2 more sources
Journal of Health Science and Medical Research (JHSMR), 2021 Objective: To identify the normal reference ranges of serum testosterone and gonadotropins in Thai fertile men, compare these levels among different age groups, and assess their relationships with body mass index (BMI). Material and Methods: One hundred
Thakorn Pruktanakul +4 more
doaj +1 more source
The Nipple-Areola Complex for Criminal Identification [PDF]
, 2019 In digital and multimedia forensics, identification of child sexual offenders based on digital evidence images is highly challenging due to the fact that the offender's face or other obvious characteristics such as tattoos are occluded, covered, or not visible at all. Nevertheless, other naked body parts, e.g., chest are still visible. Some researchers
arxiv +1 more source
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
Nature Communications, 2017 Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition.
M. Asim +29 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Androgen receptor: structure, role in prostate cancer and drug discovery
Acta Pharmacologica Sinica, 2014 Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade
M. Tan +4 more
semanticscholar +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source