Results 61 to 70 of about 348,703 (339)

Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

Reproductive Medicine and Biology, 2019
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood.
Satoko Osuka, Natsuki Nakanishi, Tomohiko Murase, Tomoko Nakamura, Maki Goto, Akira Iwase, Fumitaka Kikkawa   +6 more
doaj   +1 more source

Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway

Cancer Medicine, 2023
Background Since the human papillomavirus vaccines do not eliminate preexisting infections, nonsurgical alternative approaches to cervical intraepithelial neoplasia (CIN) have been required.
Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai, Junpei Iwadare, Ayumi Matsuoka, Kayo Kayahashi, Kousho Wakae, Masamichi Muramatsu, Satoru Kyo, Yasuhiko Yamamoto, Yasunari Mizumoto, Takiko Daikoku, Hiroshi Fujiwara   +19 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients [PDF]

, 2008
Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters.
Bartlett, J.M.S., Edwards, J., Grimsley, S.L.S., McGlynn, L.M., Mukherjee, R., Traynor, P.   +5 more
core   +3 more sources

Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies

Journal of Asthma and Allergy, 2022
Guo-Qiang Zhang,1 Saliha Selin Özuygur Ermis,1,2 Madeleine Rådinger,1 Apostolos Bossios,3,4 Hannu Kankaanranta,1,5,6 Bright Nwaru1,7 1Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden ...
Zhang GQ, Özuygur Ermis SS, Rådinger M, Bossios A, Kankaanranta H, Nwaru B   +5 more
doaj  

Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen

Frontiers in Endocrinology, 2011
Brain aromatase is expressed only in the nerve cells of specific brain regions with a transient peak at the neonatal period when sexual behaviors become organized. Aromatase knockout (ArKO) mouse, generated to give light on the physiological functions of
Nobuhiro eHarada, Toru eWakatsuki, Shin-ichiro eHonda   +2 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1 [PDF]

, 2018
Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses significant therapeutic challenges.
Ahmad, Imran, Blomme, Arnaud, Edwards, Joanne, Fleming, Janis, Hamdy, Freddie C., Harle, Victoria, Hedley, Ann, Leung, Hing Y., Loveridge, Carolyn, Mackay, Gillian, Mui, Ernest, Patel, Rachana, Repiscak, Peter, Salji, Mark, Sansom, Owen J., Teo, Katy, van den Broek, Niels   +16 more
core   +2 more sources

Evaluating the Term ‘Disorders of Sex Development’: A Multidisciplinary Debate

Social Medicine, 2018
In 2014, almost 10 years after the 2005 International Consensus Conference on Intersex in Chicago, one of the conference co-organisers, under the auspices of a number of international paediatric endocrinology societies, launched the Global DSD Update to ...
Natalie Delimata, Margaret Simmonds, Michelle O’Brien, Georgiann Davis, Richard Auchus, Karen Lin-Su   +5 more
doaj  

Mitogen Activated Protein kinase signal transduction pathways in the prostate

Cell Communication and Signaling, 2004
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty, Maroni Paul D, Meacham Randall B, Koul Hari K   +3 more
doaj   +1 more source