Results 61 to 70 of about 434,055 (399)

PCONet: A Convolutional Neural Network Architecture to Detect Polycystic Ovary Syndrome (PCOS) from Ovarian Ultrasound Images [PDF]

arXiv, 2022
Polycystic Ovary Syndrome (PCOS) is an endrocrinological dysfunction prevalent among women of reproductive age. PCOS is a combination of syndromes caused by an excess of androgens - a group of sex hormones - in women. Syndromes including acne, alopecia, hirsutism, hyperandrogenaemia, oligo-ovulation, etc. are caused by PCOS. It is also a major cause of
arxiv  

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer

Frontiers in Oncology, 2019
Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic ...
Q. Feng, B. He
semanticscholar   +1 more source

Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature

BJUI Compass, Volume 4, Issue 1, Page 24-43, January 2023., 2023
Abstract Context Testicular germ cell tumour (TGCT) survivors are potentially at risk of developing osteoporosis, because of increased risk for disturbed bone remodelling associated with hypogonadism and anti‐cancer treatment. A number of studies show bone loss and increased fracture risk in TGCT survivors, but data are scarce.
Josephina P. M. Vrouwe, Pauline M. L. Hennus, Neveen A. T. Hamdy, Susanne Osanto, Peter‐Paul M. Willemse   +4 more
wiley   +1 more source

Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility

Frontiers in Endocrinology, 2018
Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes.
Julia S. Barthold, Richard Ivell
doaj   +1 more source

Daytime Exposure to Blue-Enriched Light Counters the Effects of Sleep Restriction on Cortisol, Testosterone, Alpha-Amylase and Executive Processes

Frontiers in Neuroscience, 2020
Sleep debt is becoming a better acknowledged cause of physiological stress and neurobehavioral deficits with major public-health concerns. We investigated whether exposure to blue light during daytime could be an efficient countermeasure to limit sleep ...
Brice Faraut, Brice Faraut, Thomas Andrillon, Catherine Drogou, Catherine Drogou, Caroline Gauriau, Alexandre Dubois, Aurélie Servonnet, Pascal Van Beers, Pascal Van Beers, Mathias Guillard, Mathias Guillard, Danielle Gomez-Merino, Danielle Gomez-Merino, Fabien Sauvet, Fabien Sauvet, Mounir Chennaoui, Mounir Chennaoui, Damien Léger, Damien Léger   +19 more
doaj   +1 more source

Towards Personalized Prostate Cancer Therapy Using Delta-Reachability Analysis [PDF]

, 2014
Recent clinical studies suggest that the efficacy of hormone therapy for prostate cancer depends on the characteristics of individual patients. In this paper, we develop a computational framework for identifying patient-specific androgen ablation therapy schedules for postponing the potential cancer relapse.
arxiv   +1 more source

Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1 [PDF]

, 2018
Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses significant therapeutic challenges.
Ahmad, Imran, Blomme, Arnaud, Edwards, Joanne, Fleming, Janis, Hamdy, Freddie C., Harle, Victoria, Hedley, Ann, Leung, Hing Y., Loveridge, Carolyn, Mackay, Gillian, Mui, Ernest, Patel, Rachana, Repiscak, Peter, Salji, Mark, Sansom, Owen J., Teo, Katy, van den Broek, Niels   +16 more
core   +2 more sources

Androgen Signaling in Prostate Cancer.

Cold Spring Harbor Perspectives in Medicine, 2017
The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has remained a mainstay of therapy for advanced disease.
Charles Dai, H. Heemers, N. Sharifi
semanticscholar   +1 more source

Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models

BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023
Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang, Toni Rose Jue, Jeff Holst, Jennifer H. Gunter   +3 more
wiley   +1 more source

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity [PDF]

, 2011
Peer reviewedPublisher ...
A Godoy, A Haelens, A Monge, AN Vis, AO Brinkmann, B Cinar, B Gottlieb, B He, B He, B He, B Tiwary, BA Evans, C Cai, CA Berrevoets, CA Heinlein, Colin W. Hay, CT Kesler, CT Wu, D Ricketson, DJ Lamb, EB Askew, EP Gelmann, ER Hyytinen, G Buchanan, G Chen, G Verrijdt, GN Brooke, GP Reddy, H Faus, H Takahashi, HI Scher, HJ Dubbink, HT Bruggenwirth, I Ahrens-Fath, Iain J. McEwan, IJ McEwan, J Brodie, J Duff, J Edwards, J Geller, J Reid, J Tan, J Veldscholte, JA Locke, JD Wilson, Jean-Marc A. Lobaccaro, K Evaul, K Haapala, KB Cleutjens, KE Knudsen, KH Chang, KK Waltering, KM Lakshman, LJ Blok, M Fu, M Jagla, M Marcelli, M Sun, M Uemura, M Welsh, ME Baker, ME Taplin, ME Taplin, ME Taplin, MJ Linja, MM Centenera, MM Shen, N Mononen, OA O'Mahony, PA Watson, PE de Ruiter, Q Wang, R Betney, R Chenna, R Hu, R Schule, RJ Andersen, S Baron, S Haile, S Koochekpour, SM Dehm, SM Dehm, SM Powell, SS Dutt, SS Taneja, ST Page, TH Li, TM Tanner, W Li, Y Chen, Y Gluzman, Y Niu, Y Niu, Y Ogino, YD Li, Z Guo   +95 more
core   +5 more sources