Results 71 to 80 of about 310,378 (283)

Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells

BioTechniques, 2021
Due to the public health concerns of endocrine-disrupting chemicals, there is an increasing demand to develop improved high-throughput detection assays for enhanced exposure control and risk assessment. A substrate-free, autobioluminescent HEK293ARE/Gal4-
Tingting Xu, Madison Gilliam, Gary Sayler, Steven Ripp, Dan Close   +4 more
doaj   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

Reproductive Medicine and Biology, 2019
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood.
Satoko Osuka, Natsuki Nakanishi, Tomohiko Murase, Tomoko Nakamura, Maki Goto, Akira Iwase, Fumitaka Kikkawa   +6 more
doaj   +1 more source

Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway

Cancer Medicine, 2023
Background Since the human papillomavirus vaccines do not eliminate preexisting infections, nonsurgical alternative approaches to cervical intraepithelial neoplasia (CIN) have been required.
Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai, Junpei Iwadare, Ayumi Matsuoka, Kayo Kayahashi, Kousho Wakae, Masamichi Muramatsu, Satoru Kyo, Yasuhiko Yamamoto, Yasunari Mizumoto, Takiko Daikoku, Hiroshi Fujiwara   +19 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Androgens and bone [PDF]

Steroids, 2009
Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione.
Sundeep Khosla, Bart L. Clarke
openaire   +2 more sources

Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies

Journal of Asthma and Allergy, 2022
Guo-Qiang Zhang,1 Saliha Selin Özuygur Ermis,1,2 Madeleine Rådinger,1 Apostolos Bossios,3,4 Hannu Kankaanranta,1,5,6 Bright Nwaru1,7 1Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden ...
Zhang GQ, Özuygur Ermis SS, Rådinger M, Bossios A, Kankaanranta H, Nwaru B   +5 more
doaj  

Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen

Frontiers in Endocrinology, 2011
Brain aromatase is expressed only in the nerve cells of specific brain regions with a transient peak at the neonatal period when sexual behaviors become organized. Aromatase knockout (ArKO) mouse, generated to give light on the physiological functions of
Nobuhiro eHarada, Toru eWakatsuki, Shin-ichiro eHonda   +2 more
doaj   +1 more source

AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome

Journal of Clinical Endocrinology and Metabolism, 2017
Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk.
M. O’Reilly, Punith Kempegowda, Mark Walsh, A. Taylor, Konstantinos N. Manolopoulos, W. J. Allwood, R. Semple, D. Hebenstreit, W. Dunn, J. Tomlinson, W. Arlt   +10 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source