BMC Research Notes, 2011 Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil +5 more
doaj +1 more source
Therapeutic potential of TRPM8 antagonists in prostate cancer
Scientific Reports, 2021 Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear.
Marzia Di Donato +8 more
doaj +1 more source
Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma
Zhongliu Fangzhi Yanjiu, 2023 Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua +4 more
doaj +1 more source
Canalization of the Vestibular Plate in the Absence of Urethral Fusion Characterizes Development of the Human Clitoris: The Single Zipper Hypothesis. [PDF]
, 2016 PurposeWe characterized the early gestation development of the female external genitalia using optical projection tomography to visualize anatomical structures at high resolution.Materials and methodsFirst and early second trimester human female fetal ...
Baskin, Laurence +8 more
core +2 more sources
The epigenetic function of androgen receptor in prostate cancer progression
Frontiers in Cell and Developmental Biology, 2023 Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer.
Takahiro Sawada +9 more
doaj +1 more source
Effect of water deprivation for three consecutive days on the proportions of androgen receptor-immunolabeled supraoptic nucleus magnoneurons in Wistar rats [PDF]
, 2022 The androgen receptor is an androgen-dependent transcription factor that belongs to the nuclear receptor superfamily. When the androgen receptor is not bound to its ligand, it is mainly localized in the cytoplasm, bound to chaperone proteins, which ...
Benarab Souhila +7 more
core
Overcharging of zinc ion in the structure of zinc finger protein is needed for DNA binding stability [PDF]
, 2019 The zinc finger structure where a Zn2+ ion binds to 4 cysteine or histidine amino acids in a tetrahedral structure is very common motif of nucleic acid binding proteins. The corresponding interaction model is present in 3% of the genes of human genome.
arxiv +1 more source
Scientific Reports, 2021 Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs.
Diana Trnski +10 more
doaj +1 more source
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. [PDF]
, 2013 Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly ...
Evans, Christopher P +11 more
core
Androgen receptor epigenetics.
Translational andrology and urology, 2013 The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Xin Yuan, Steven P. Balk, Changmeng Cai
openaire +3 more sources