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Androgen Receptors in Human Breast Cancer and Female Canine Mammary Tumors [PDF]

Molecules
This review explores the potential role of androgens in human breast cancer and female canine mammary tumors. Human breast cancer is one of the most common cancers affecting women globally, while female canine mammary tumors provide a natural model for ...
Vladimir Vidović, Ivana Davidov, Zoran Ružić, Mihajlo Erdeljan, Annamaria Galfi Vukomanović, Bojana Blagojević   +5 more
doaj   +2 more sources

Masculinizing hormone therapy effect on breast tissue: Changes in estrogen and androgen receptors in transgender female-to-male mastectomies [PDF]

Breast, 2023
Purpose: Almost two percent of individuals in the United States identify as gender non-conforming. In the female-to-male (FTM) transgender population, masculinizing hormone therapy with testosterone is commonly prescribed in gender transition.
Manita Chaum, Sara Grossi, Jiaxi Chen, Vivian Hu, Edward Ray, Armando Giuliano, Shikha Bose   +6 more
doaj   +2 more sources

Prognostic Value of Androgen Receptor Expression in Bladder Tumors [PDF]

Translational Research in Urology, 2023
Introduction: The present study was conducted with the aim of investigating the prognostic value of androgen receptor expression in bladder tumors.Methods: This study was conducted in the urology department of Imam Reza Hospital on male patients with ...
Salman Soltani, Sajjad Sadeghpour, Mahmood Reza Kalantari, Hamidreza Ghorbani, Majid Khadem Rezaiyan, Atena Aghaee, Mahmoud Tavakoli, Hamideh Heydari, Samira Assarian   +8 more
doaj   +1 more source

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok, P E, de Ruiter, A O, Brinkmann   +2 more
openaire   +3 more sources

Androgen receptor mutations [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors. At least three pathological situations are associated with abnormal androgen receptor structure and function: androgen ...
Brinkmann, A. O., Jenster, G., Ris-Stalpers, C., van der Korput, J. A., Brüggenwirth, H. T., Boehmer, A. L., Trapman, J.   +6 more
openaire   +3 more sources

Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction

Molecules, 2021
Flavonoids are plant bioactives that are recognized as hormone-like polyphenols because of their similarity to the endogenous sex steroids 17β-estradiol and testosterone, and to their estrogen- and androgen-like activity. Most efforts to verify flavonoid
Giulia D’Arrigo, Eleonora Gianquinto, Giulia Rossetti, Gabriele Cruciani, Stefano Lorenzetti, Francesca Spyrakis   +5 more
doaj   +1 more source

Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development. The cloning of the human androgen receptor cDNA and the elucidation of the genomic organization of the corresponding gene has enabled us to study androgen ...
Brinkmann, A. O., Kuiper, G. G., Ris-Stalpers, C., van Rooij, H. C., Romalo, G., Trifiro, M., Mulder, E., Pinsky, L., Schweikert, H. U., Trapman, J.   +9 more
openaire   +2 more sources

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua, CAI Shiliang, LIU Donghong, CHEN Hongsen, CAO Guangwen   +4 more
doaj   +1 more source

Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs

Animals, 2021
Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER)
Adam Brodzki, Wojciech Łopuszyński, Yolanda Millan, Marcin R. Tatara, Piotr Brodzki, Katarzyna Kulpa, Natalia Minakow   +6 more
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Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: Study in paraffin tissue sections

BMC Cancer, 2005
Background Steroid action is mediated, in addition to classical intracellular receptors, by recently identified membrane sites, that generate rapid non-genomic effects.
Theodoropoulos Panayiotis A, Anezinis Ploutarchos, Nomikos Michael, Darivianaki Katherine, Kampa Marilena, Kogia Christina, Dambaki Constantina, Castanas Elias, Stathopoulos Efstathios N   +8 more
doaj   +1 more source