Results 31 to 40 of about 75,567 (147)

Insights into Androgen Receptor Action in Lung Cancer

Endocrines, 2023
Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer.
Darko Durovski, Milica Jankovic, Stefan Prekovic   +2 more
doaj   +1 more source

Immunohistochemical expression of androgen receptors in prostate carcinoma and benign prostatic hyperplasia [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Prostate carcinoma (PCa) and its parent organ are influenced by hormones, which is used for therapeutic purposes. Through androgen receptors (AR) androgens influence cell growth and function, proliferation, differentiation, apoptosis ...
Trivunić-Dajko Sandra, Bogdanović Jovo, Fejsa-Levakov Aleksandra, Živojinov Mirjana, Đolai Matilda   +4 more
doaj   +1 more source

Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. [PDF]

PLoS ONE, 2012
The production of mature sperm is reliant on androgen action within the testis, and it is well established that androgens act on receptors within the somatic Sertoli cells to stimulate male germ cell development.
Peter G Stanton, Pavel Sluka, Caroline F H Foo, Andrew N Stephens, A Ian Smith, Robert I McLachlan, Liza O'Donnell   +6 more
doaj   +1 more source

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
doaj   +1 more source

Phosphorylation of androgen receptor isoforms [PDF]

Biochemical Journal, 2004
Phosphorylation of the human AR (androgen receptor) is directly correlated with the appearance of at least three AR isoforms on an SDS/polyacrylamide gel. However, it is still not clear to what extent phosphorylation is involved in the occurrence of isoforms, which sites are phosphorylated and what are the functions of these phosphosites.
Wong, H.Y., Burghoorn, J.A., van Leeuwen, M., de Ruiter, P.E., Schippers, E., Blok, L.J., Li, K.W., Dekker, H.L., de Jong, L., Trapman, J., Grootegoed, J.A., Brinkmann, A.O.   +11 more
openaire   +6 more sources

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

Reproductive Biology and Endocrinology
Gonadal steroids are involved in the organization and programming of several neural systems. The main objective of this study was to determine whether androgen activity in the early postnatal stage influenced the long-term expression of androgen and ...
Rocío García-Úbeda, Jose Manuel Fernandez-Garcia, Ulises Primo, Daniela Grassi, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos, Beatriz Carrillo   +8 more
doaj   +1 more source

ARD1/NAA10 acetylation in prostate cancer

Experimental and Molecular Medicine, 2018
Prostate cancer: Preventing androgen receptor activation Blocking the addition of an acetyl group to androgen receptors by Arrest-defect-1 protein (ARD1) might be an effective strategy for halting prostate cancer progression.
Katherine J. Kuhns, Guanyi Zhang, Zehua Wang, Wanguo Liu   +3 more
doaj   +1 more source

Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]

PLoS ONE, 2012
Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy, Ana Monteiro, Margaret Abel   +2 more
doaj   +1 more source

Lipid Metabolic Disorders in Neurodegenerative Diseases – Role of Androgen Receptor

Eurasian Journal of Medicine, 2023
The challenge of managing neurodegenerative disorders is a worldwide concern, especially in the aging population. Neurodegenerative diseases are a varied group of disorders that are characterized by progressive degeneration of the structure and function
Satvika Sharma, Avneet Saini, D.K. Dhawan   +2 more
doaj   +1 more source

Androgens and androgen receptor signaling in prostate tumorigenesis [PDF]

Journal of Molecular Endocrinology, 2014
Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at ...
Ye, Zhou, Eric C, Bolton, Jeremy O, Jones   +2 more
openaire   +2 more sources