Results 21 to 30 of about 75,567 (147)

Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: Study in paraffin tissue sections

BMC Cancer, 2005
Background Steroid action is mediated, in addition to classical intracellular receptors, by recently identified membrane sites, that generate rapid non-genomic effects.
Theodoropoulos Panayiotis A, Anezinis Ploutarchos, Nomikos Michael, Darivianaki Katherine, Kampa Marilena, Kogia Christina, Dambaki Constantina, Castanas Elias, Stathopoulos Efstathios N   +8 more
doaj   +1 more source

A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors

Ecotoxicology and Environmental Safety, 2021
Production of polychlorinated biphenyls (PCBs) was banned a long time ago because of their harmful health effects but humans continue to be exposed to residual PCBs in the environment.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus

Acta Dermato-Venereologica, 2018
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder.
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan   +6 more
doaj   +1 more source

Immunohistochemical features of ovarian structure at polycystic ovary syndrom depending on the age

Patologìâ, 2012
peculiarities of proliferation factors and androgens receptors expression in women with PCOS, depending on age were analyzed. It was revealed that pronounced expression of PCNA, cytokeratin and androgen receptors in stroma and intengification of PCNA ...
I. Yu. Ganzhiy
doaj   +1 more source

Androgen Receptor and Mechanism of Androgen Action

Annals of Medicine, 1993
Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner.
O A, Jänne, J J, Palvimo, P, Kallio, M, Mehto   +3 more
openaire   +2 more sources

Androgen receptors in meningiomas [PDF]

Cancer, 1988
Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT).
J J, Olson, D W, Beck, J W, MacIndoe, P, Min-Loh   +3 more
openaire   +2 more sources

Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Molecular Cancer, 2008
Background Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling.
Gravanis Achilleas, Föller Michael, Konstantinidis Georgios, Anagnostopoulou Vasileia, Charalampopoulos Ioannis, Papadopoulou Natalia, Alevizopoulos Konstantinos, Lang Florian, Stournaras Christos   +8 more
doaj   +1 more source

DRUG THERAPY FOR ANDROGEN-POSITIVE BREAST CANCER

Сибирский онкологический журнал, 2021
There are some types of breast cancer (BC) that depend on their molecular characteristics. However, lately researchers provide date regarding the presence of additional receptors of triple negative breast cancer (TNBC).
A. D. Zikiryakhodjhaev, A. A. Fedenko, M. V. Starkova, V. S. Surkova, M. V. Sedova   +4 more
doaj   +1 more source

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok, P E, de Ruiter, A O, Brinkmann   +2 more
openaire   +3 more sources

Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. [PDF]

PLoS ONE, 2013
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases androgen synthesis, a phenomenon attributed to the accompanying hyperinsulinemia.
Fabio V Comim, Kate Hardy, Stephen Franks   +2 more
doaj   +1 more source