Results 41 to 50 of about 238,876 (343)
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
Clinical science, 2017 The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
A. Lucas-Herald +4 more
semanticscholar +1 more source
Androgens in cervical cancer: Their role in epidemiology and biology
iScienceSummary: This comprehensive review delves into the significance of androgens in cervical cancer, examining both epidemiological evidence and the underlying biological mechanisms.
Yang Gu, Qing Mu, Dali Cheng
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Remarks on the Hormonal Background of the Male Equivalent of Polycystic Ovary Syndrome
Prague Medical Report, 2021 The hypothesis that the most common female endocrine disease, the polycystic ovarian syndrome (PCOS), has a male equivalent, has recently become more widely accepted.
Luboslav Stárka, Michaela Dušková
doaj +1 more source
COVID‐19, androgens, and androgenic alopecia [PDF]
Dermatological Reviews, 2020 AbstractThe severity of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in males may be due to the higher androgen expression. It is also known that androgen sensitivity is correlated with androgenic alopecia. The “Gabrin sign” identifies those with severe androgen alopecia (Hamilton Norwood scale = 3–7) who are at a higher risk for ...
Wambier, Carlos Gustavo +3 more
openaire +2 more sources
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
Scientific ReportsThe classical androgens, testosterone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens, are generally included in diagnostic steroid evaluations of androgen excess and deficiency disorders and monitored in ...
Amanda C. Swart +7 more
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Androgens and cardiac diseases
Monaldi Archives for Chest Disease, 2013 Although androgens have been considered deleterious for the cardiovascular system, recent data have demonstrated favourable testosterone effects on cardiac and vascular remodeling and clinical outcome.
Vittorio Bianchi, Alessandro Mezzani
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High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche
Frontiers in Pediatrics, 2023 ObjectiveThe purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA).
Eleni Magdalini Kyritsi +8 more
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