Results 41 to 50 of about 176,817 (345)

Androgen regulation of the androgen receptor coregulators [PDF]

BMC Cancer, 2008
Abstract Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also be important in the progression of prostate cancer. The
Urbanucci, Alfonso, Waltering, Kati K, Suikki, Hanna E, Helenius, Merja A, Visakorpi, Tapio   +4 more
openaire   +4 more sources

Androgens in cervical cancer: Their role in epidemiology and biology

iScience
Summary: This comprehensive review delves into the significance of androgens in cervical cancer, examining both epidemiological evidence and the underlying biological mechanisms.
Yang Gu, Qing Mu, Dali Cheng
doaj   +1 more source

Androgens and prostate disease

Asian Journal of Andrology, 2014
A growing body of literature has established the anabolic benefi ts of testosterone (T) therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects ...
Lori A Cooper, Stephanie T Page
doaj   +1 more source

Insights into Androgen Receptor Action in Lung Cancer

Endocrines, 2023
Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer.
Darko Durovski, Milica Jankovic, Stefan Prekovic   +2 more
doaj   +1 more source

The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?

Reproductive Biology and Endocrinology, 2011
Background Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature.
Gleicher Norbert, Weghofer Andrea, Barad David H   +2 more
doaj   +1 more source

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells

Cells, 2021
Prostate cancer (PC) is one of the most widespread malignancies among males worldwide. The androgen receptor (AR) plays a major role in prostate cancer development and progression and is the main target of PC therapy.
Marzia Di Donato, Pia Giovannelli, Maria Vittoria Barone, Ferdinando Auricchio, Gabriella Castoria, Antimo Migliaccio   +5 more
doaj   +1 more source

Androgenetic alopecia: a review [PDF]

, 2017
Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma, Fortuna, MARIA CATERINA, Lenzi, Andrea, Lolli, Francesca, Lombardo, Francesco, Pallotti, Francesco, Rossi, Alfredo, Sansone, Andrea   +7 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

Biology, 2023
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver
Riccardo Nevola, Giovanni Tortorella, Valerio Rosato, Luca Rinaldi, Simona Imbriani, Pasquale Perillo, Davide Mastrocinque, Marco La Montagna, Antonio Russo, Giovanni Di Lorenzo, Maria Alfano, Maria Rocco, Carmen Ricozzi, Klodian Gjeloshi, Ferdinando Carlo Sasso, Raffaele Marfella, Aldo Marrone, Loreta Anesti Kondili, Nicolino Esposito, Ernesto Claar, Domenico Cozzolino   +20 more
doaj   +1 more source

Membrane androgen receptors may mediate androgen reinforcement [PDF]

Psychoneuroendocrinology, 2010
Anabolic-androgenic steroid (AAS) abuse is widespread. Moreover, AAS are reinforcing, as shown by self-administration in rodents. However, the receptors that transduce the reinforcing effects of AAS are unclear. AAS may bind to classical nuclear androgen receptors (ARs) or membrane receptors. We used two approaches to examine the role of nuclear ARs in
Satoru M, Sato, Jamie A, Johansen, Cynthia L, Jordan, Ruth I, Wood   +3 more
openaire   +2 more sources