The gene network and knowledge base on human thermoregulation [PDF]
Reconstruction and analysis of gene networks regulating biological processes are among the modern methodological approaches for studying complex biological systems that ensure the vital activity of organisms.
E. V. Ignatieva +7 more
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Investigation of metabolic features of glioblastoma tissue and the peritumoral environment using targeted metabolomics screening by LC-MS/MS and gene network analysis [PDF]
The metabolomic profiles of glioblastoma and surrounding brain tissue, comprising 17 glioblastoma samples and 15 peritumoral tissue samples, were thoroughly analyzed in this investigation.
N. V. Basov +18 more
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Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms [PDF]
Drought is a critical factor limiting the productivity of bread wheat (Triticum aestivum L.), one of the key agricultural crops. Wheat adaptation to water deficit is ensured by complex molecular genetic mechanisms, including the coordinated work of ...
M. A. Kleshchev +9 more
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Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem [PDF]
Background Currently, more than 150 million people worldwide suffer from lymphedema. It is a chronic progressive disease characterized by high-protein edema of various parts of the body due to defects in lymphatic drainage.
Olga V. Saik +6 more
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Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to Rhizoctonia solani under excess nitrogen fertilization using gene network reconstruction and analysis methods [PDF]
Although nitrogen fertilizers increase rice yield, their excess can impair plant resistance to diseases, particularly sheath blight caused by Rhizoctonia solani.
E. A. Antropova +9 more
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A comparative analysis of regional permeability of the material for the fixation of andsystem
The dentist on therapeutic reception is always a matter of choice, of choosing a particular method or material in a particular clinical situation. This relates to the question of the application of endodontic systems: for or against? Unfortunately, it is
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Candidate SNP markers of changes in the expression levels of the human SCN9A gene as a hub gene for pain generation, perception, response and anesthesia [PDF]
In this work, we for the first time performed a comprehensive bioinformatics analysis of 568 human genes that, according to the NCBI Gene database as on September 15, 2024, were associated with pain generation, perception and anesthesia.
P. A. Dotsenko +8 more
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shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma [PDF]
One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma.
Drevytska Tatiana +13 more
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Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease and vascular parkinsonism [PDF]
Parkinson’s disease (PD) and vascular parkinsonism (VP) are characterized by similar neurological syndromes but differ in pathogenesis, morphology, and therapeutic approaches.
A. A. Makarova +11 more
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Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice [PDF]
Anxiety is a normotypic human condition, and like any other emotion has an adaptive value. But excessively high or low anxiety has negative consequences for adaptation, which primarily determines the importance of studying these two extreme conditions ...
E. G. Vergunov +4 more
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