Results 1 to 10 of about 514,226 (119)

miRNA-associated gene networks reveal potential candidate markers for Alzheimer’s disease [PDF]

Frontiers in Molecular Biosciences
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory and cognitive decline. Recent studies highlight the significant role of microRNAs (miRNAs) in regulating genes related to AD.
Shujuan Pan, Yanfang Zhou, Xiaoyu Wang, Jinghui Tong, Yanli Li, Junchao Huang, Song Chen, Yimin Cui, Zhiren Wang, Yun-Long Tan   +9 more
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Modeling the Flowering Activation Motif during Vernalization in Legumes: A Case Study of M. trancatula

Life, 2023
In many plant species, flowering is promoted by the cold treatment or vernalization. The mechanism of vernalization-induced flowering has been extensively studied in Arabidopsis but remains largely unknown in legumes.
Maria A. Duk, Vitaly V. Gursky, Maria G. Samsonova, Svetlana Yu. Surkova   +3 more
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Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines

Biomolecules, 2021
Neuroblastoma (NBL) is a pediatric cancer responsible for more than 15% of cancer deaths in children, with 800 new cases each year in the United States alone.
Daniele Mercatelli, Nicola Balboni, Alessandro Palma, Emanuela Aleo, Pietro Paolo Sanna, Giovanni Perini, Federico Manuel Giorgi   +6 more
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Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection

Journal of Integrative Bioinformatics, 2023
Hepatocellular carcinoma (HCC) has been associated with hepatitis C viral (HCV) infection as a potential risk factor. Nonetheless, the precise genetic regulatory mechanisms triggered by the virus, leading to virus-induced hepatocarcinogenesis, remain ...
Antropova Evgeniya A., Khlebodarova Tamara M., Demenkov Pavel S., Volianskaia Anastasiia R., Venzel Artur S., Ivanisenko Nikita V., Gavrilenko Alexandr D., Ivanisenko Timofey V., Adamovskaya Anna V., Revva Polina M., Kolchanov Nikolay A., Lavrik Inna N., Ivanisenko Vladimir A.   +12 more
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Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine

Cells, 2022
MicroRNAs (miRNAs) create systems networks and gene-expression circuits through molecular signaling and cell interactions that contribute to health imbalance and the emergence of cardiovascular disorders (CVDs).
Fani Chatzopoulou, Konstantinos A. Kyritsis, Christos I. Papagiannopoulos, Eleftheria Galatou, Nikolaos Mittas, Nikoleta F. Theodoroula, Andreas S. Papazoglou, Efstratios Karagiannidis, Maria Chatzidimitriou, Anna Papa, Georgios Sianos, Lefteris Angelis, Dimitrios Chatzidimitriou, Ioannis S. Vizirianakis   +13 more
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Gestational Age Dependence of the Maternal Circulating Long Non-Coding RNA Transcriptome During Normal Pregnancy Highlights Antisense and Pseudogene Transcripts

Frontiers in Genetics, 2021
In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level.
Erica L. Kleinbrink, Nardhy Gomez-Lopez, Nardhy Gomez-Lopez, Nardhy Gomez-Lopez, Donghong Ju, Bogdan Done, Anton-Scott Goustin, Adi L. Tarca, Adi L. Tarca, Adi L. Tarca, Roberto Romero, Roberto Romero, Roberto Romero, Roberto Romero, Roberto Romero, Leonard Lipovich   +15 more
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Heat and drought induced transcriptomic changes in barley varieties with contrasting stress response phenotypes

Frontiers in Plant Science, 2022
Drought and heat stress substantially impact plant growth and productivity. When subjected to drought or heat stress, plants exhibit reduction in growth resulting in yield losses.
Ramamurthy Mahalingam, Naveen Duhan, Rakesh Kaundal, Andrei Smertenko, Taras Nazarov, Phil Bregitzer   +5 more
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Dynamics of the Gene Regulatory Network of HIV-1 and the Role of Viral Non-coding RNAs on Latency Reversion

Frontiers in Physiology, 2018
The use of latency reversing agents (LRAs) is currently a promising approach to eliminate latent reservoirs of HIV-1. However, this strategy has not been successful in vivo.
Antonio Bensussen, Christian Torres-Sosa, Christian Torres-Sosa, Christian Torres-Sosa, Ramón A. Gonzalez, José Díaz   +5 more
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Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Epigenetics & Chromatin, 2017
Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal   +7 more
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Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization

Frontiers in Cell and Developmental Biology, 2022
Dendritic cells (DCs) can be used for therapeutic vaccination against cancer. The success of this therapy depends on efficient tumor-antigen presentation to cytotoxic T lymphocytes (CTLs) and the induction of durable CTL responses by the DCs.
Xin Lai, Xin Lai, Christine Keller, Guido Santos, Guido Santos, Niels Schaft, Niels Schaft, Jan Dörrie, Jan Dörrie, Julio Vera, Julio Vera   +10 more
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