Results 71 to 80 of about 17,482 (309)

Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells

Biomolecules
Inhalation anesthesia stands as a pivotal modality within clinical anesthesia practices. Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic effects, exerting bidirectional influences on the physiological state of the body and ...
Xiaotong Hao, Yuan Li, Hairong Gao, Zhilin Wang, Bo Fang   +4 more
doaj   +1 more source

ANESTHETIC, ANALGETIC, HYPNOTIC – ARE THE TERMS IMPORTANT?

Вестник анестезиологии и реаниматологии, 2017
The review is devoted to pharmacology of the general anesthesia in the light of current understanding of this event and as a medical technique. The discussion covers the classification of medications used for general anesthesia basing on action mechanisms
A. E. Karelov, K. M. Lebedinskiy, V. I. Buravtsov   +2 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Liquid mixtures involving fluorinated alcohols: The equation of state (p, r, T, x) of (Ethanol + Trifluoroethanol) Experimental and Simulation [PDF]

, 2012
Liquid mixtures involving fluorinated alcohols: The equation of state (p, r, T, x) of (Ethanol + Trifluoroethanol) Experimental and Simulation Pedro Duartea, Djêide Rodriguesa, Marcelo Silvaa, Pedro Morgadoa, Luís Martinsa,b and Eduardo J. M. Filipea*
Duarte, P, Filipe, E, Martins, L, Morgado, P, Rodrigues, D, Silva, M   +5 more
core  

How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes:A Summary of Current State of Evidence [PDF]

, 2019
The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational
Aguirre, Jose A., Bencic, Ivanka, Borgeat, Alain, Buggy, Donal, Cama, Allessandro, Condron, Claire, Connolly, Cara, Eintrei, Christina, Eroles, Pilar, Forget, Patrice, Guerrero Orriach, Jose Luis, Gupta, Anil, Hales, Tim G., Ionescu, Daniela, Johnson, Mark, Kabata, Pawel, Kirac, Iva, Ma, Daqing, Mokini, Zhirajr, Retsky, Michael, Sandrucci, Sergio, Siekmann, Wiebke, Votta-Vellis, Gina, Štefančić, Ljilja   +23 more
core   +5 more sources

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Early, Subclinical Hematological Changes Associated with Occupational Exposure to High Levels of Nitrous Oxide

Toxics, 2018
This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, nitrous oxide, isoflurane, and sevoflurane was associated with any hematological changes. This historical cohort study was performed in 2018 at
Fatemeh Amiri, Masoud Neghab, Fatemeh Kargar Shouroki, Saeed Yousefinejad, Jafar Hassanzadeh   +4 more
doaj   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Sevoflurane and desflurane protect cholinergic-induced bronchoconstriction of hyperreactive airways in rabbits [PDF]

, 2018
Purpose: The potential of desflurane to alter respiratory mechanics in the presence of bronchial hyperresponsiveness (BHR) is still a subject of debate.
Boda, Krisztina, Fontao, Fabienne, Habre, Walid, Jánosi, Tibor, Myers, Carole, Peták, Ferenc   +5 more
core  

Perioperative Neurocognitive Disorder: State of the Preclinical Science. [PDF]

, 2020
The purpose of this article is to provide a succinct summary of the different experimental approaches that have been used in preclinical postoperative cognitive dysfunction research, and an overview of the knowledge that has accrued. This is not intended
Culley, Deborah J, Eckenhoff, Maryellen F, Eckenhoff, Roderic G, Goodlin, Sarah J, Maze, Mervyn, Orser, Beverley A, Terrando, Niccolò, Wei, Huafeng, Whittington, Robert A, Xie, Zhongcong, Zuo, Zhiyi   +10 more
core