Results 11 to 20 of about 314,110 (215)

Sodium channels as targets for volatile anesthetics

Frontiers in Pharmacology, 2012
The molecular mechanisms of modern inhaled anesthetics although widely used in clinical settings are still poorly understood. Considerable evidence supports effects on membrane proteins such as ligand- and voltage-gated ion channels of excitable cells ...
Karl F. Herold, Hugh C. Hemmings
doaj   +2 more sources

Effects of Anesthetics on Barrier Tissue Function

Journal of Immunology Research, 2019
Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are ...
Fujing Wang, Yanhui Li, Changlei Cui, Zhaoping Xue, Haichun Ma   +4 more
doaj   +2 more sources

Volatile anesthetics affect macrophage phagocytosis.

PLoS ONE, 2019
BackgroundPerioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication.
Hui Zha, Erika Matsunami, Nathan Blazon-Brown, Sophia Koutsogiannaki, Lifei Hou, Weiming Bu, Hasan Babazada, Kirsten C Odegard, Renyu Liu, Roderic G Eckenhoff, Koichi Yuki   +10 more
doaj   +2 more sources

Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics

BMC Pulmonary Medicine
Background Volatile anesthetics are gaining recognition for their benefits in long-term sedation of mechanically ventilated patients with bacterial pneumonia and acute respiratory distress syndrome.
Claudia Scheffzük, Johanna Lührmann, Robin Brinkmann, Dominika Biedziak, Kristina Gloystein, Patrick Kellner, Cordula Stamme   +6 more
doaj   +2 more sources

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus. [PDF]

, 2012
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear.
Dodt Hans-Ulrich, Hans-Ulrich Dodt, Eder, Matthias, Ranft, Andreas, Ludwig von Meyer, Zieglgänsberger Walter, Ranft Andreas, von Meyer, Ludwig, Klaus Becker, Eberhard Kochs, Becker, K., Walter Zieglgänsberger, Kochs Eberhard, Matthias Eder, Kochs, Eberhard, Becker Klaus, Andreas Ranft, von Meyer, L., Dodt, H., Dodt, H. U., Becker, Klaus, Zieglgänsberger, Walter, Eder, M., Eder Matthias, Zieglgänsberger, W., Meyer, Ludwig von, von Meyer Ludwig, Dodt, Hans-Ulrich, Ranft, A., Kochs, E.   +29 more
core   +1 more source

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Frontiers in Neural Circuits, 2023
BackgroundHow volatile anesthetics work remains poorly understood. Modulations of synaptic neurotransmission are the direct cellular mechanisms of volatile anesthetics in the central nervous system.
Jingxuan Qiu, Jingxuan Qiu, Yaoxin Yang, Yaoxin Yang, Jin Liu, Wenling Zhao, Qian Li, Qian Li, Tao Zhu, Peng Liang, Cheng Zhou   +10 more
doaj   +1 more source

Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1 [PDF]

PeerJ, 2015
Proper glycemic control is one of the most important goals in perioperative patient management. Insulin secretion from pancreatic β-cells in response to an increased blood glucose concentration plays the most critical role in glycemic control.
Kengo Suzuki, Yoshifumi Sato, Shinichi Kai, Kenichiro Nishi, Takehiko Adachi, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +2 more sources

Use of Volatile Anesthetics in Extracorporeal Circulation [PDF]

, 2012
Background and objectivesThe use of volatile anesthetics in cardiac surgery is not recent. Since the introduction of halothane in clinical practice, several cardiac surgery centers started to use these anesthetics constantly.ContentIn the last years a ...
Nigro Neto, Caetano, Tardelli, Maria Angela, Paulista, Paulo Henrique Dagola   +2 more
core   +1 more source

SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. [PDF]

PLoS ONE, 2011
Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure ...
Andrew P Wojtovich, Teresa A Sherman, Sergiy M Nadtochiy, William R Urciuoli, Paul S Brookes, Keith Nehrke   +5 more
doaj   +1 more source

Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence.
Dana Raub, Katharina Platzbecker, Stephanie D. Grabitz, Xinling Xu, Karuna Wongtangman, Stephanie B. Pham, Kadhiresan R. Murugappan, Khalid A. Hanafy, Ala Nozari, Timothy T. Houle, Samir M. Kendale, Matthias Eikermann   +11 more
doaj   +1 more source