Results 51 to 60 of about 17,615 (256)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Seqüência de fluxo de gás fresco para início da anestesia com baixo fluxo: aplicação clínica do estudo teórico de Mapleson Secuencia de flujo de gas fresco para inicio de la anestesia con bajo flujo: aplicación clínica del estudio teórico de Mapleson Fresh-gas flow sequence at the start of low-flow anesthesia: clinical application of Mapleson’s theoretical study

Revista Brasileira de Anestesiologia, 2002
JUSTIFICATIVA E OBJETIVOS: Em estudo teórico, Mapleson utilizando um modelo farmacocinético multicompartimental, com um homem padrão de 40 anos e 70 kg, demonstrou que, com fluxo de gás fresco (FGF) inicial igual à ventilação pulmonar total, sendo depois
Marisa Miziara Jreige Borges, Renato Ângelo Saraiva   +1 more
doaj   +1 more source

Radiation‐Resistant Kr‐Selective MOF With Record Kr/Xe Selectivity at Elevated Pressure

Advanced Science, EarlyView.
ABSTRACT The separation of Kr/Xe from spent nuclear fuel off‐gas is critical, yet most current adsorbents exhibit Xe‐Kr co‐adsorption under elevated pressures, posing challenges for industrial pressure swing adsorption processes. Herein, we present and evaluate a metal‐organic framework, CALF‐20M‐w, engineered for molecular sieving separation of Kr/Xe ...
Qihang Tian, Yinhui Li, Qingkuan Meng, Shizhen Liu, Yongzheng Wang, Bin Chen, Heping Ma   +6 more
wiley   +1 more source

Exertional rhabdomyolysis and heat stroke : beware of volatile anesthetic sedation [PDF]

, 2017
In view of the enormous popularity of mass sporting events such as half-marathons, the number of patients with exertional rhabdomyolysis or exercise-induced heat stroke admitted to intensive care units (ICUs) has increased over the last decade.
Baets, Jonathan, De Bleecker, Jan, Heytens, Karel, Heytens, Luc, Verbrugghe, Walter   +4 more
core   +2 more sources

Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer

Advanced Science, EarlyView.
The novel intravesical delivery system exhibits GSH‐responsive drug release, enabling a synergistic therapeutic strategy that combines ferroptosis, ICD and PTT. ABSTRACT Ferroptosis, a newly recognized form of regulated cell death, has emerged as a promising strategy in cancer therapy.
Xiaojian Xu, Rui Liang, Anguo Zhao, Jun Zhang, Rongkang Li, Yang Liu, Dashi Deng, Qi Zhuang, Lisha Liu, Lei Peng, Miao Li, Xuedong Wei, Yuhua Huang, Shaohua Zhang, Liang Cheng, Jianquan Hou   +15 more
wiley   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. [PDF]

, 2020
Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.
Cao, Jimin, Christopher, Theodore, Gao, Erhe, Guo, Rui, Jiao, Liyuan, Lau, Wayne Bond, Lopez, Bernard, Ma, Xin-Liang, Wang, Yajing, Xie, Dina, Zhang, Yanqing, Zhao, Jianli   +11 more
core   +1 more source

Solid Ethanol as a Renewable, Low‐Toxicity, Electron‐Beam Direct Write, and Biomedical Material

Advanced Science, EarlyView.
3D ice lithography (3DIL) enables the fabrication of intricate submicrometer objects using ethanol as a renewable starting material. This study combines process optimization, structural and material analysis, and biomedical applications, from cell culture scaffolds to the patterning of neurostimulation electrodes, demonstrating performance in both in ...
Bruno Perdigão, Bingdong Chang, Gwendoline A. E. Anand, Lechan Tao, Kayeon Kim, Anne Zebitz Eriksen, Malte Alexander Schönhoff, Guilherme Ferreira, Xiyuan Liu, Su Genelioglu, Joachim Lyngholm‐Kjærby, Neha Zahoor, Johan Ulrik Lind, Alice Bastos da Silva Fanta, Thomas Willum Hansen, Changsi Cai, Anpan Han   +16 more
wiley   +1 more source

Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit.

PLoS ONE, 2020
Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to ...
Peng Zhang, Yao Li, Ting Xu
doaj   +1 more source