Results 51 to 60 of about 314,110 (215)

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit.

PLoS ONE, 2020
Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to ...
Peng Zhang, Yao Li, Ting Xu
doaj   +1 more source

Electrochemical Fluorination of Partially Fluorinated Dialkylethers. Synthesis of Sevoflurane Derivatives (CF3)2CHOCHF2, (CF3)2CHOCF3, and (CF3)2CFOCF3

Chemistry – A European Journal, EarlyView.
Electrochemical fluorination (ECF, Simons process) is a valuable method for the fluorination of partially fluorinated dialkyl ethers, providing an inexpensive, scalable, and safe access to partially fluorinated ethers with a higher fluorine content and the perfluorinated analogues that are hardly accessible using other fluorination techniques ...
Tanja Knuplez, Leon N. Schneider, Erik R. Csapo, Peer Kirsch, Nikolai V. Ignat'ev, Maik Finze   +5 more
wiley   +1 more source

Inhaled Volatiles for Status Asthmaticus, Epilepsy, and Difficult Sedation in Adult ICU and PICU: A Systematic Review

Critical Care Explorations
OBJECTIVES:. Inhaled volatile anesthetics support management of status asthmaticus (SA), status epilepticus (SE), and difficult sedation (DS). This study aimed to evaluate the effectiveness, safety, and feasibility of using inhaled anesthetics for SA, SE,
Kevin Gorsky, MD, Sean Cuninghame, MD, Kesikan Jayaraj, RN, Marat Slessarev, MD, PhD, FRCPC, Conall Francoeur, MD, Davinia E. Withington, BM, FRCA, MRCP(UK), Jennifer Chen, Brian H. Cuthbertson, MBBS, PhD, Claudio Martin, MD, Martin Chapman, MD, FRCPC, Saptharishi Lalgudi Ganesan, MBBS, MD, DM, FACNS, Nicole McKinnon, MD, PhD, Angela Jerath, MD, MSc, FANZCA, FRCPC, on behalf of the SAVE-ICU Study Investigators, Martin Chapman, Damon Scales, Julie Nardi, Beth Linseman, Phil Lau, Boris Yakubov, Eily Shaw, Francois Carrier, Emmanuel Charbonney, Michaël Chassé, Martin Girard, Antoine Halwagi, Guillaume Plourde, Han Ting Wang, Frédérick D’Aragon, Maxime Tissot-Therrien, François Lamontagne, Dominique Bérard, Yiorgos Alexandros Cavayas, Martin Albert, Francis Bernard, Karim Serri, David Williamson, Virginie Williams, Patricia Martinez Barrios, Sabrina Araujo De Franca, Etienne J. Couture, Adreanne Côté, Mathieu Simon, Pierre-Alexis Lépine, Dave Gleeton, John Basmaji, Marat Slessarev, Ahmed Hegazy, Tracey Bentall, Eileen Campbell, Michelle Stephens, Tim Winterburn, Roupen Hatzakorzian, Kosar Khwaja, Peter Goldberg, Jason Shahin, Jeremy Richard Grushka, Jonathan Hooper, Sherissa Microys, Hilary Meggison, David Leilipovitz, Jessica Haines, Irene Watpool, Rebecca Porteous, Stephanie Dunster, Sylvie Bourbonnais, Ewan Goligher, Lorenzo Del Sorbo, Niall Ferguson, Philip Graham, Michael Long, Tina Yan, Denise Morris, Maria Kobylecky, Hesham Abdelhady, Tina Romagnuolo, Bourke Tillman, Ian Randall, Elizabeth Wilcox, Michael Jacka, Oleksa Rewa, Vincent Lau, Sean Bagshaw, Nadia Baig   +83 more
doaj   +1 more source

A Green Scalable Method to Prepare Zr Oxide Dicarboxylate Metal–Organic Frameworks

European Journal of Inorganic Chemistry, EarlyView.
A greener approach for large‐scale synthesis of MIL‐140(Zr) family for cultural heritage preservation. We report the synthesis of a series of isoreticular hydrophobic microporous zirconium dicarboxylate metal–organic frameworks (MOFs), MIL‐140(Zr)s, under green ambient pressure conditions.
Debanjan Chakraborty, Sanchari Dasgupta, Oleksii Kolmykov, Maria Inês Severino Neves, Vanessa Pimenta, Abeer Mohtar, Cátia Freitas, Iurii Dovgaliuk, Moises L. Pinto, Georges Mouchaham, Farid Nouar, Christian Serre   +11 more
wiley   +1 more source

A case of malignant hyperthermia that was difficult to be differentiated from oral antipsychotic polypharmacy-associated neuroleptic malignant syndrome

JA Clinical Reports, 2016
Malignant hyperthermia (MH) occurred during anesthesia with volatile inhalation anesthetics in a patient under treatment with multiple oral antipsychotic drugs and with a history of multi-acting receptor-targeted antipsychotic drug (MARTA)-induced ...
Yoshiki Hara, Yutaka Hosoya, Ryo Deguchi, Shigehito Sawamura   +3 more
doaj   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Preparation of Dräger Atlan A350 and General Electric Healthcare Carestation 650 anesthesia workstations for malignant hyperthermia susceptible patients

BMC Anesthesiology, 2021
Background Patients at risk of malignant hyperthermia need trigger-free anesthesia. Therefore, anesthesia machines prepared for safe use in predisposed patients should be free of volatile anesthetics. The washout time depends on the composition of rubber
Sebastian Heiderich, Christian Thoben, Nils Dennhardt, Terence Krauß, Robert Sümpelmann, Stefan Zimmermann, Michael Reitz, Henrik Rüffert   +7 more
doaj   +1 more source

Decreasing Frontal Electroencephalogram Alpha Power and Increasing Sensitivity to Volatile Anesthetics Over 3 Surgeries Within 7 Months: A Case Report.

, 2019
Depth of anesthesia (DoA) monitors are widely used during general anesthesia to guide individualized dosing of hypnotics. Other than age and specific drugs, there are few reports on which comorbidities may influence the brain and the resultant ...
David Reineke, Hartwich, Volker, Stucki, Monika, Rummel, Christian, Hight, Darren, Trevor Hirschi, Darren Hight, Christian Rummel, Reineke, David, Kaiser, Heiko, Monika Stucki, Volker Hartwich, Hirschi, Trevor, Heiko A. Kaiser   +13 more
core   +1 more source