Results 61 to 70 of about 17,615 (256)

Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation [PDF]

, 2018
Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of its mechanism of action remains incomplete.
Carnevale, Vincenzo, Covarrubias, Manuel, Eckenhoff, Roderic G., Granata, Daniele, Yang, Elaine   +4 more
core   +1 more source

Terrestrial Cyborg Insects for Real‐Life Applications

Advanced Intelligent Systems, EarlyView.
This article reviews the development of terrestrial cyborg insects from their emergence in 1997 to mid‐2025, examining three key aspects: locomotion control methods, associated challenges with proposed solutions, and practical applications. Framing these biohybrid systems as insect‐scale mobile robots, the review provides foundational insights for new ...
Hai Nhan Le, Lachlan Fitzgerald, Phuoc Thien Phan, Robbie Wilson, Christofer Clemente, Huu Duoc Nguyen, Hirotaka Sato, Hoang‐Phuong Phan, Peter Ross McAree, Thanh Nho Do, Tat Thang Vo‐Doan   +10 more
wiley   +1 more source

Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

eLife, 2021
Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented, and there has been significant
Julia Stokes, Arielle Freed, Rebecca Bornstein, Kevin N Su, John Snell, Amanda Pan, Grace X Sun, Kyung Yeon Park, Sangwook Jung, Hailey Worstman, Brittany M Johnson, Philip G Morgan, Margaret M Sedensky, Simon C Johnson   +13 more
doaj   +1 more source

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites. [PDF]

, 2018
Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic NaV channel NaChBac have demonstrated that propofol promotes channel activation ...
Bondarenko, Vasyl, Carnevale, Vincenzo, Covarrubias, Manuel, Dailey, William P., Eckenhoff, Roderic G., Granata, Daniele, Klein, Michael L., Tang, Pei, Wang, Yali, Wells, Marta M., Woll, Kellie, Xu, Yan, Yang, Elaine   +12 more
core   +1 more source

Frequency of Predisposing Factor of Nausea and Vomiting After Chest Surgery Under General Anaesthesia [PDF]

, 2019
Background: Postoperative nausea and vomiting are common and distressing postsurgical symptoms. These symptoms are of particular concern in outpatient surgery because they may require additional direct resources, such as supplies and antiemetic ...
Bhatti, S. U. (Sami), Hanif, A. (Asif), Rehman, U. A. (Usman), Shahnawaz, A. (Ayesha), Ulhaq, Z. (Zabinfat), Ullah, Q. (Qudrat)   +5 more
core   +2 more sources

Isovolumic relaxation strain imaging is an accurate and sensitive approach for detection of active diastolic dysfunction: A preclinical study

Animal Models and Experimental Medicine, EarlyView.
A modified approach was developed to accurately identify the isovolumetric relaxation time (IVRT) using an apical three‐chamber view. Compared with conventional echocardiography, isovolumic relaxation strain imaging (IVSI) helps to detect the earlier alternations of diastolic function in transverse aortic constriction (TAC) mice.
Jingjing Liang, Juncheng Wang, Jun Cheng, Yanggan Wang   +3 more
wiley   +1 more source

Coverage Generosity of Novel Antirheumatic Drugs in Medicare Advantage and Stand‐Alone Part D Plans

Arthritis &Rheumatology, EarlyView.
Objective We examine coverage of self‐administered disease‐modifying antirheumatic drugs (DMARDs) in Medicare Part D. Methods Using 2022–2026 Part D formulary data, we assessed coverage of the following DMARD classes that treat relapsed rheumatoid arthritis (RA): tumor necrosis factor (TNF) inhibitors, T cell costimulatory modulator, interleukin‐6 (IL ...
Youngmin Kwon, Robert W. Corty, Stacie B. Dusetzina   +2 more
wiley   +1 more source

Inhaled Volatiles for Status Asthmaticus, Epilepsy, and Difficult Sedation in Adult ICU and PICU: A Systematic Review

Critical Care Explorations
OBJECTIVES:. Inhaled volatile anesthetics support management of status asthmaticus (SA), status epilepticus (SE), and difficult sedation (DS). This study aimed to evaluate the effectiveness, safety, and feasibility of using inhaled anesthetics for SA, SE,
Kevin Gorsky, MD, Sean Cuninghame, MD, Kesikan Jayaraj, RN, Marat Slessarev, MD, PhD, FRCPC, Conall Francoeur, MD, Davinia E. Withington, BM, FRCA, MRCP(UK), Jennifer Chen, Brian H. Cuthbertson, MBBS, PhD, Claudio Martin, MD, Martin Chapman, MD, FRCPC, Saptharishi Lalgudi Ganesan, MBBS, MD, DM, FACNS, Nicole McKinnon, MD, PhD, Angela Jerath, MD, MSc, FANZCA, FRCPC, on behalf of the SAVE-ICU Study Investigators, Martin Chapman, Damon Scales, Julie Nardi, Beth Linseman, Phil Lau, Boris Yakubov, Eily Shaw, Francois Carrier, Emmanuel Charbonney, Michaël Chassé, Martin Girard, Antoine Halwagi, Guillaume Plourde, Han Ting Wang, Frédérick D’Aragon, Maxime Tissot-Therrien, François Lamontagne, Dominique Bérard, Yiorgos Alexandros Cavayas, Martin Albert, Francis Bernard, Karim Serri, David Williamson, Virginie Williams, Patricia Martinez Barrios, Sabrina Araujo De Franca, Etienne J. Couture, Adreanne Côté, Mathieu Simon, Pierre-Alexis Lépine, Dave Gleeton, John Basmaji, Marat Slessarev, Ahmed Hegazy, Tracey Bentall, Eileen Campbell, Michelle Stephens, Tim Winterburn, Roupen Hatzakorzian, Kosar Khwaja, Peter Goldberg, Jason Shahin, Jeremy Richard Grushka, Jonathan Hooper, Sherissa Microys, Hilary Meggison, David Leilipovitz, Jessica Haines, Irene Watpool, Rebecca Porteous, Stephanie Dunster, Sylvie Bourbonnais, Ewan Goligher, Lorenzo Del Sorbo, Niall Ferguson, Philip Graham, Michael Long, Tina Yan, Denise Morris, Maria Kobylecky, Hesham Abdelhady, Tina Romagnuolo, Bourke Tillman, Ian Randall, Elizabeth Wilcox, Michael Jacka, Oleksa Rewa, Vincent Lau, Sean Bagshaw, Nadia Baig   +83 more
doaj   +1 more source

A case of malignant hyperthermia that was difficult to be differentiated from oral antipsychotic polypharmacy-associated neuroleptic malignant syndrome

JA Clinical Reports, 2016
Malignant hyperthermia (MH) occurred during anesthesia with volatile inhalation anesthetics in a patient under treatment with multiple oral antipsychotic drugs and with a history of multi-acting receptor-targeted antipsychotic drug (MARTA)-induced ...
Yoshiki Hara, Yutaka Hosoya, Ryo Deguchi, Shigehito Sawamura   +3 more
doaj   +1 more source

Preparation of Dräger Atlan A350 and General Electric Healthcare Carestation 650 anesthesia workstations for malignant hyperthermia susceptible patients

BMC Anesthesiology, 2021
Background Patients at risk of malignant hyperthermia need trigger-free anesthesia. Therefore, anesthesia machines prepared for safe use in predisposed patients should be free of volatile anesthetics. The washout time depends on the composition of rubber
Sebastian Heiderich, Christian Thoben, Nils Dennhardt, Terence Krauß, Robert Sümpelmann, Stefan Zimmermann, Michael Reitz, Henrik Rüffert   +7 more
doaj   +1 more source