Results 211 to 220 of about 107,707,414 (242)

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia

Blood, 2005
Abstract Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the formation and stabilization of the blood vessel network during embryogenesis. In adults, Ang1 is associated with blood vessel stabilization and recruitment of perivascular cells, whereas Ang2 acts to counter these actions.
Tuomas, Tammela, Anne, Saaristo, Marja, Lohela, Tohru, Morisada, Jenny, Tornberg, Camilla, Norrmén, Yuichi, Oike, Katri, Pajusola, Gavin, Thurston, Toshio, Suda, Seppo, Yla-Herttuala, Kari, Alitalo   +11 more
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Enhancement of Muscle Flap Hemodynamics by Angiopoietin-1

Annals of Plastic Surgery, 2002
Angiopoietin-1 (Ang-1) constitutes a novel family of endothelial cell-specific angiogenic factors. Ang-1 functions mainly in remodeling, maturation, and stabilization of blood vessels. Its direct role in the process of angiogenesis remains unknown.
Raffi, Gurunluoglu, Przemyslaw, Lubiatowski, Corey K, Goldman, Kevin, Carnevale, Maria, Siemionow   +4 more
openaire   +2 more sources

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Science, 1998
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later ...
C, Suri, J, McClain, G, Thurston, D M, McDonald, H, Zhou, E H, Oldmixon, T N, Sato, G D, Yancopoulos   +7 more
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Macrophage Polarization with Angiopoietin-1 Peptide QHREDGS

ACS Biomaterials Science & Engineering, 2019
Currently, clinics are faced with the difficult task of treating non-healing wounds. While the treatment regimen varies between different patients and wounds, a non-healing wound can be a significant detriment to a patient's quality of life, thus highlighting the need for more effective treatments.
Serena Mandla, Locke Davenport Huyer, Yufeng Wang, Milica Radisic   +3 more
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Circulating Angiopoietin-1 to Angiopoietin-2 Ratio Is an Independent Prognostic Factor for Survival in Newly Diagnosed Patients With Multiple Myeloma Who Received Therapy With Novel Antimyeloma Agents

International Journal of Cancer, 2012
The circulating levels of several angiogenic cytokines [angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), angiogenin and basic fibroblast growth factor (bFGF)] were evaluated in 174 consecutive patients with newly
Evangelos Terpos, Efstathios Kastritis, Athanasios Dimopoulos   +2 more
exaly   +1 more source

Impact of angiopoietin-1 in mesothelioma progression

European Respiratory Journal, 2013
Introduction: Angiopoietins-1 (Ang-1) is a key regulator of tumor angiogenesis and stimulates the proliferation and migration of malignant mesothelioma (MM) cells that express its receptor (Tie-2) in vitro. Despite this, the impact of Ang-1 in MM progression in vivo has not been examined before. Aim: To elucidate the role of Ang-1 the
Sophia Magkouta, Charis Moschos, Magda Spella, Maria-Eleni Vazakidou, Ioannis Psallidas, Apostolis Pappas, Georgios Stathopoulos, Ioannis Kalomenidis   +7 more
openaire   +1 more source

Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma

Journal of Hepatology, 2004
Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC.The expression of Angiopoietin-1 and Angiopoietin-2 mRNAs in cultured hepatoma cells under hypoxic conditions and in HCC and ...
Takuji, Torimura, Takato, Ueno, Motoaki, Kin, Riko, Harada, Eitaro, Taniguchi, Toru, Nakamura, Ryuichiro, Sakata, Osamu, Hashimoto, Masaharu, Sakamoto, Ryukichi, Kumashiro, Michio, Sata, Osamu, Nakashima, Hirohisa, Yano, Masamichi, Kojiro   +13 more
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Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development

Current Oncology Reports, 2019
The purpose of this review is to discuss the current understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis. This review also focuses on preclinical and clinical data published to date that have evaluated Tie2-angiopoietin inhibition.Tie2 inhibition has shown significant promise in preclinical models, notable for ...
Jessica, Gillen, Debra, Richardson, Kathleen, Moore   +2 more
openaire   +2 more sources

Adipose tissue growth and regression are regulated by angiopoietin-1

Biochemical and Biophysical Research Communications, 2003
Adipose tissue is unique in its plasticity, capacity for vascular remodeling, and susceptibility to angiogenesis inhibitors. We hypothesize that these characteristics are enabled by maintaining relatively immature adipose vessels to facilitate vascular/tissue remodeling.
Susan M, Dallabrida, David, Zurakowski, Shu-Ching, Shih, Lois E, Smith, Judah, Folkman, Karen S, Moulton, Maria A, Rupnick   +6 more
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Immunolocalization of angiopoietin 1 in human peritoneal endometriotic lesions

Fertility and Sterility, 2004
To analyze the expression of angiopoietin 1 (ANGPT1) in pigmented and nonpigmented endometriosis implants and specify its role in the interaction of angiogenic factors.Experimental retrospective study.University hospital.Eighty-two sections from 201 laparoscopic tissue samples of 43 female patients.Biopsies of peritoneal endometriotic lesions of ...
Dorothee Maria, Gescher, Uta, Berndorff, Annette, Meyhoefer-Malik, Pierre, Moubayed, Eduard, Malik   +4 more
openaire   +2 more sources