Results 91 to 100 of about 97,423,779 (276)

Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels

Critical Care, 2019
Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery.
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Willem W. J. van Strien, Jisca Majolée, Robert Szulcek, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom   +8 more
doaj   +1 more source

Imbalance of Angiopoietin-1 and Angiopoetin-2 in Severe Dengue and Relationship with Thrombocytopenia, Endothelial Activation, and Vascular Stability [PDF]

, 2012
Contains fulltext : 108223.pdf (Publisher’s version ) (Open Access)Abstract. The pathogenesis of plasma leakage during dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is largely unknown.
Faradz, S.M.H., Djamiatun, K., Michels, M., Fijnheer, R., de Groot, P.G., Ven, A.J.A.M. van der, Griffioen, A.W., Sebastian, S., de Mast, Q.   +8 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy

, 2004
Pericyte loss is an early pathologic feature of diabetic retinopathy, consistently present in retinae of diabetic humans and animals. Because pericyte recruitment and endothelial cell survival are controlled, in part, by the angiopoietin/Tie2 ligand ...
Wagner, P, Breier, G, Renner, O, Feng, Y, Vom Hagen, F, Krzizok, T, Brownlee, M, Hammes, HP, Lin, J, Deutsch, Urban   +9 more
core   +1 more source

Plasma angiopoietin-2 in clinical acute lung injury [PDF]

, 2012
BackgroundAngiopoietin-2 is a proinflammatory mediator of endothelial injury in animal models, and increased plasma angiopoietin-2 levels are associated with poor outcomes in patients with sepsis-associated acute lung injury.
Matthay, Michael A, Abbott, Jason, Gallagher, Diana, Thompson, B Taylor, Calfee, Carolyn S   +4 more
core   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

Acta Neuropathologica Communications, 2018
After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular growth factors that play an important role in vascular stabilization.
Hemant Kumar, Hyemin Choi, Min-Jae Jo, Hari Prasad Joshi, Manjunatha Muttigi, Dario Bonanomi, Sung Bum Kim, Eunmi Ban, Aeri Kim, Soo-Hong Lee, Kyoung-Tae Kim, Seil Sohn, Xiang Zeng, Inbo Han   +13 more
doaj   +1 more source

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source

Exploring some pro-inflammatory cytokines and adipokines as novel biomarkers in polycystic ovary syndrome

Italian Journal of Medicine
Non-communicable diseases are more likely to affect women with polycystic ovarian syndrome (PCOS), in particular, mostly ascribed to the existence of low-grade chronic inflammation brought on by adipokines and proinflammatory cytokines.
Dlvin Akif Mustafa, Parween Abdulsamad Ismail   +1 more
doaj   +1 more source

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source